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Hepatic encephalopathy as a complication of liver disease

Stephan vom Dahl  Gerald Kircheis  Dieter Haussinger  
【摘要】:正 Hepatic encephalopathy (HE) is a frequentcomplication of chronic liver disease. It is definedas a characteristic functional and reversiblealteration of the mental state, due to impaired liverfunction and/or increased portosystemic shunting. In the brain of HE patients, neurons appearmorphologically normal, but astrocytes show signsof Alzheimer type Ⅱ degeneration, i. e. nuclearenlargement, peripheral margination of chromatin

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