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Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats

【摘要】:正 Aim:To investigate the role of histamine in memory deficits induced by MK-801infusion into the ventral hippocampus in rats.Methods:An 8-arm radial maze(4arms baited)was used to assess spatial memory.Results:Bilateral ventralintrahippocampal(ih)infusion of MK-801(0.3 μg/site),an N-methyl-D-aspartate(NMDA)antagonist,impaired the retrieval process in both working memory andreference memory.Intrahippocampal injection of histamine(25 or 50 ng/site)orintraperitoneal(ip)injection of histidine(25,50 or 100 mg/kg)markedly amelio-rated the spatial memory deficits induced by MK-801.Both the histamine H_1 an-tagonist pyrilamine(0.5 or 1.0 μg/site,ih)and the H2 antagonist cimetidine(2.5 μg/site,ih)abolished the ameliorating effect of histidine( 100 mg/kg,ip)on reference memorydeficits,but not that on working memory deficits induced by MK-801.Conclusion:The results indicate that histamine in the ventral hippocampus can ameliorateMK-801-induced spatial memory deficits,and that histamine's effect on referencememory is mediated by postsynaptic histamine H_1 and H_2 receptors.

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