收藏本站
收藏 | 投稿 | 手机打开
二维码
手机客户端打开本文

Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia

Xiao-Hua Wang  Wei Jiang  Si-Yuan Zhang  Bin-Bin Nie  Yi Zheng  Feng Yan  Jian-Feng Lei  Tian-Long Wang  
【摘要】:Hypothermia is an important protective strategy against global cerebral ischemia following cardiac arrest. However, the mechanisms of hypothermia underlying the changes in different regions and connections of the brain have not been fully elucidated. This study aims to identify the metabolic nodes and connection integrity of specific brain regions in rats with global cerebral ischemia that are most affected by hypothermia treatment. ~(18)F-fluorodeoxyglucose positron emission tomography was used to quantitatively determine glucose metabolism in different brain regions in a rat model of global cerebral ischemia established at 31–33℃. Diffusion tensor imaging was also used to reconstruct and explore the brain connections involved. The results showed that, compared with the model rats established at 37–37.5℃, the rat models of global cerebral ischemia established at 31–33℃ had smaller hypometabolic regions in the thalamus and primary sensory areas and sustained no obvious thalamic injury. Hypothermia selectively preserved the integrity of the anterior forebrain mesocircuit, exhibiting protective effects on the brain during the global cerebral ischemia. The study was approved by the Institutional Animal Care and Use Committee at Capital Medical University(approval No. XW-AD318-97-019) on December 15, 2019.

知网文化
【相似文献】
中国期刊全文数据库 前19条
1 ;Distinct proteins in cortex of rats with closed traumatic brain injury detected by a WCX-2 protein chip[J];Neural Regeneration Research;2007年06期
2 周进,王君;The protective effect of subhypothermia on brain of patient with ischemic cerebrovascular disease on different time[J];中国临床康复;2003年01期
3 ;Association between the fMRI manifestations of activated brain areas and muscle strength in patients with space-occupying lesions in motor cortex[J];Neural Regeneration Research;2006年04期
4 Guang-qiang Hu;Xi Du;Yong-jie Li;Xiao-qing Gao;Bi-qiong Chen;Lu Yu;;Inhibition of cerebral ischemia/reperfusion injuryinduced apoptosis: nicotiflorin and JAK2/STAT3 pathway[J];Neural Regeneration Research;2017年01期
5 Chin Hee Mun;Won Taek Lee;Kyung Ah Park;Jong Eun Lee;;Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia[J];Neural Regeneration Research;2010年23期
6 ;Changes in synapse quantity and growth associated protein 43 expression in the motor cortex of focal cerebral ischemic rats following catalpol treatment[J];Neural Regeneration Research;2011年18期
7 ;Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia[J];Acta Pharmacologica Sinica;2004年04期
8 Yang-Kun Chen;Wei-Min Xiao;Defeng Wang;Lin Shi;Winnie CW Chu;Vincent CT Mok;Ka Sing Wong;Gabor S Ungvari;Wai Kwong Tang;;Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women[J];Neural Regeneration Research;2013年04期
9 ;Remodeling of motor cortex function in acute cerebral infarction patients following human urinary kallidinogenase A functional magnetic resonance imaging evaluation after 6 months[J];Neural Regeneration Research;2012年11期
10 Abass Eidizadeh;George Trendelenburg;;Focusing on the protective effects of metallothionein-Ⅰ/Ⅱ in cerebral ischemia[J];Neural Regeneration Research;2016年05期
11 Jeong Pyo Seo;Sung Ho Jang;;Disappearance of unaffected motor cortex activation by repetitive transcranial magnetic stimulation in a patient with cerebral infarct[J];Neural Regeneration Research;2014年07期
12 ;Parietal cortex contributions to information granules following memory consolidation[J];Chinese Science Bulletin;2010年24期
13 ;Synaptic NMDA receptors in the insular cortex contribute to neuropathic pain[J];Science Foundation in China;2014年01期
14 ;Effects of melatonin on learning abilities, cholinergic fibers and nitric oxide synthase expression in rat cerebral cortex[J];Neural Regeneration Research;2006年08期
15 Yin Yuan;Xiu-yue Xu;Jie Lao;Xin Zhao;;Proteomic analysis of trans-hemispheric motor cortex reorganization following contralateral C_7 nerve transfer[J];Neural Regeneration Research;2018年02期
16 Alexandria M.Reynolds;Denise M.Peters;Jennifer M.C.Vendemia;Lenwood P.Smith;Raymond C.Sweet;Gordon C.Baylis;Debra Krotish;Stacy L.Fritz;;Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxelbased lesion symptom mapping study[J];Neural Regeneration Research;2014年07期
17 Wei Chen;Han-Ting Zhang;Shu-Cun Qin;;Neuroprotective Effects of Molecular Hydrogen: A Critical Review[J];Neuroscience Bulletin;2021年03期
18 Sang Seok Yeo;Sung Ho Jang;;A change in injured corticospinal tract originating from the premotor cortex to the primary motor cortex in a patient with intracerebral hemorrhage[J];Neural Regeneration Research;2012年12期
19 Juliana Dalibor Neves;Régis Gemerasca Mestriner;Carlos Alexandre Netto;;Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage[J];Neural Regeneration Research;2018年01期
中国重要会议论文全文数据库 前20条
1 Tian hailong;He wei;Zhong yuan;Zhang chunyun;Wang zhigang;;The clinical significance of "Yellow fluorescence" navigation combined with the intraoperative cortical electrical stimulation in resection of low grade glioma located in the brain motor cortex[A];第十五届中国医师协会神经外科医师年会摘要集[C];2020年
2 Meiling Wen;Ya Jin;Hao Zhang;Xiaoou Sun;Wen Tan;;Proteomic analysis of focal cerebral ischemia/reperfusion injury in rats indicated changes of multiple cellular pathways[A];2018年中国质谱学术大会(CMSC 2018)论文集[C];2018年
3 Jing Wang;Huaide Liu;Weihua Jin;Hong Zhang;Quanbin Zhang;;Structure-activity relationship of sulfated hetero-polysaccharides and sulfated galactofucan polysaccharides on protective effect of dopaminergic neuron in vivo and in vitro[A];第十二届海洋药物学术年会会刊[C];2015年
4 Chen Jing;Shogo Ninomiya;Shigeyuki Esumi;Takaichi Fukuda;Wu Shengxi;Nobuaki Tamamaki;;Leptomeninges as a new pool for neurogenesis in adult mammalian cerebral cortex following amygdala kindling[A];中国解剖学会2015年年会论文文摘汇编[C];2015年
5 尹训涛;徐君海;韩燕;葛海涛;黄瑞旺;张栋;徐文坚;Alan C Evans;汤煜春;刘树伟;;Effects of functional connectivity between anterior cingulate cortex and dorsolateral prefrontal cortex on executive control of attention in healthy individuals[A];中国解剖学会2011年年会论文文摘汇编[C];2011年
6 谢嵘;Peng Wang;Michelle Cheng;Robert Sapolsky;Xunming Ji;Heng Zhao;;m TOR cell signaling pathway contributes to the protective effects of ischemic postconditioning against stroke[A];长三角地区神经科学论坛2016暨第八次会员代表大会摘要集[C];2016年
7 ;Requirement for activation of glycine site of NMDA receptors in the rostral anterior cingulate cortex in cat pain-related negative affect[A];中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会论文摘要汇编[C];2005年
8 ;Accumulation of blood-derived microglial progenitors in cerebral cortex after acute ischemic stroke[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
9 ;Expression of iron-related proteins and alterations in iron content in the temporal cortex of parkinsonian patients[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
10 Keiji Tanaka;;Representation of object categories in activity patterns of inferotemporal cell population[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年
11 Pei Xu;Haiwei Xu;Xiaotong Tang;Le Xu;Ying Wang;Liang Guo;Zhenhui Yang;Yan Xing;Yuzhang Wu;Margaret Warner;Jan-Ake Gustafsson;Xiaotang Fan;;Liver X receptor β is essential for the differentiation of radial glial cells to oligodendrocytes in the dorsal cortex[A];第二届全国发育生物学大会论文集[C];2014年
12 Yuting Lou;Peiyu Huang;Dan Li;Zhidong Cen;Bo Wang;Jixiang Gao;Min Xuan;Hualiang Yu;Minming Zhang;Wei Luo;;Altered Brain Network Centrality in Depressed Parkinson Disease Patients[A];2015年浙江省神经病学学术年会论文汇编[C];2015年
13 于继徐;车峰远;蒋建章;;Increased Iron in Motor Cortex of Amyotrophic Lateral Sclerosis Patients:an in vivo MR Study[A];山东省2013年神经内科学学术会议暨中国神经免疫大会2013论文汇编[C];2013年
14 ;PFC control VTA DA neurons activity[A];第十二届全国神经精神药理学学术交流会论文集[C];2006年
15 Xueyan Wu;Runjie Wang;Lianzhong Wu;Qingling Meng;Lili Tu;Youyu Zhu;Yujun Shen;Yanyan Su;Huajian Wang;Shengchun Xu;Yuxian Shen;;Elevated peroxiredoxin 6 in the brain cortex in peripheral infection rats but not human[A];中国解剖学会2019年年会论文文摘汇编[C];2019年
16 DAI Xue-ling;CHANG Ping;HUANGHan-Chang;WUXue-ling;LI Xiao-xiao;JIANG Zhao-feng;;Research on Protective Effect of Chitosan Oligosaccharide on SH-SY5YCells[A];中国生物化学与分子生物学会2016年全国学术会议论文集[C];2016年
17 Kazutada Watanabe;;Neuronal protective role of neural recognition molecule NB-3 in mouse cerebral ischemia[A];中国生理学会第23届全国会员代表大会暨生理学学术大会论文摘要文集[C];2010年
18 王柠;薛偕华;林毅;方玲;慕容慎行;吴志英;;The R219K polymorphism in the A TP-binding cassette transporter 1 gene has a protective effect on atherothrombotic cerebral infarction in Chinese Han ethnic population[A];第十一届全国神经病学学术会议论文汇编[C];2008年
19 ;Brain Tumour Surgery By Using Magnetoencephalography Localization[A];中国中西医结合学会围手术期专业委员会成立大会暨第二届全国中西医结合围手术期医学专题研讨会论文集[C];2007年
20 Wu Peng;Yang Zhanjun;Jia Jiaxin;Liu Xinlang;Zhou Lili;;Effects of total flavones of Dracocephalum protection for apoptosis following cerebral injury in rat[A];中国解剖学会2019年年会论文文摘汇编[C];2019年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978