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Analyzing neural degeneration of the retina with connectomics

Charles L.Zucker  John E.Dowling  
【摘要】:正Electron microscopy (EM) provides a unique ability to visualize structural detail with a resolution orders of magnitude better than other imaging techniques.Applied conventionally,its limitation is that each acquired image represents a small area with a section thickness significantly less than 100 nm.Recently,techniques have been developed that allow thousands of relatively large serial-sections to be collected and efficiently imaged at full EM resolution,with the images then being stitched back together to produce a 3D volume.

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