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New perspectives for mesenchymal stromal cells as an adjuvant therapy for infectious disease-associated encephalopathies

Maiara N.Lima  Maria C.Barbosa-Silva  Tatiana Maron-Gutierrez  
【摘要】:Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases, and its application in infectious diseases can be of great relevance. Mesenchymal stromal cells are cells with great immunomodulatory potential; therefore, their use in clinical and preclinical studies in a variety of diseases, including central nervous system diseases, increased in the last decade. Mesenchymal stromal cells can exert their beneficial effects through several mechanisms, such as direct cell contact, through surface receptors, and also through paracrine or endocrine mechanisms. The paracrine mechanism is widely accepted by the scientific community and involves the release of soluble factors, which include cytokines, chemokines and trophic factors, and extracellular vesicles. This mini review discusses mesenchymal stromal cells mechanisms of action in neurological disorders, the neuroinflammatory process that takes place in the brain as a result of peripheral inflammation and changes in the brain's cellular scenario as a common factor in central nervous system diseases, and mesenchymal stromal cells therapy in encephalopathies. Mesenchymal stromal cells have been shown to act in neuroinflammation processes, leading to improved survival and mitigating behavioral damage. More recently, these cells have been tested in preclinical models of infectious diseases-associated encephalopathies(e.g., cerebral malaria and sepsis associated encephalopathy) and have shown satisfactory results.

中国期刊全文数据库 前19条
1 ;Acute Post-infectious Multiple Cranial Neuritis (2 Case Report)[J];神经疾病与精神卫生;2003年06期
2 Halina Cichoz-Lach;Agata Michalak;;Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy[J];World Journal of Gastroenterology;2013年01期
3 Matteo Garcovich;Maria Assunta Zocco;Davide Roccarina;Francesca Romana Ponziani;Antonio Gasbarrini;;Prevention and treatment of hepatic encephalopathy: Focusing on gut microbiota[J];World Journal of Gastroenterology;2012年46期
4 Nan Li;;Research progress in hepatic encephalopathy in recent 10 years A Web of Science-based literature analysis[J];Neural Regeneration Research;2012年34期
5 Jasmohan S Bajaj;;Minimal hepatic encephalopathy matters in daily life[J];World Journal of Gastroenterology;2008年23期
6 Sergei Mechtcheriakov;Ivo W. Graziadei;Maria Rettenbacher;Ingrid Schuster;Hartmann Hinterhuber;Wolfgang Vogel;Josef Marksteiner;;Diagnostic value of fine motor deficits in patients with low-grade hepatic encephalopathy[J];World Journal of Gastroenterology;2005年18期
7 ;Pancreatic encephalopathy in 24 patients with severe acute pancreatitis[J];Hepatobiliary & Pancreatic Diseases International;2004年04期
8 Karim M Eltawil;Marie Laryea;Kevork Peltekian;Michele Molinari;;Rifaximin vs conventional oral therapy for hepatic encephalopathy:A meta-analysis[J];World Journal of Gastroenterology;2012年08期
9 Chi-Jen Chu;Ching-Chin Hsiao;Teh-Fang Wang;Cho-Yu Chan;Fa-Yauh Lee;Full-Young Chang;Shou-Dong Lee;;Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure[J];World Journal of Gastroenterology;2005年02期
10 Stephan vom Dahl;Gerald Kircheis;Dieter Haussinger;;Hepatic encephalopathy as a complication of liver disease[J];World Journal of Gastroenterology;2001年02期
11 Lindisley Ferreira Gomides;Pedro Elias Marques;Bruno Engler Faleiros;Rafaela Vaz Pereira;Sylvia Stella Amaral;Thais Reis Lage;Gustavo Henrique Souza Resende;Patricia Alves Maia Guidine;Giselle Foureaux;Fabíola Mara Ribeiro;Fabiana Paiva Martins;Marco Antonio Peliky Fontes;Anderson José Ferreira;Remo Castro Russo;Mauro Martins Teixeira;Márcio Flávio Moraes;Antonio Lúcio Teixeira;Gustavo Batista Menezes;;Murine model to study brain,behavior and immunity during hepatic encephalopathy[J];World Journal of Hepatology;2014年04期
12 Su-Wen Li;Kai Wang;Yong-Qiang Yu;Hai-Bao Wang;Yuan-Hai Li;Jian-Ming Xu;;Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China[J];World Journal of Gastroenterology;2013年46期
13 Angelo Zullo;Cesare Hassan;Lorenzo Ridola;Roberto Lorenzetti;Salvatore MA Campo;Oliviero Riggio;;Rifaximin therapy and hepatic encephalopathy:Pros and cons[J];World Journal of Gastrointestinal Pharmacology and Therapeutics;2012年04期
14 Praveen Sharma;Barjesh Chander Sharma;Shiv Kumar Sarin;;Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis[J];Hepatobiliary & Pancreatic Diseases International;2010年01期
15 Madan Raj Aryal;Smith Giri;Naba Raj Mainali;Karen Smith;;Hashimoto's encephalopathy presenting as acute cognitive decline in an elderly male[J];World Journal of Neurology;2013年01期
16 ;Neuroprotection of aucubin in primary diabetic encephalopathy[J];Science in China(Series C:Life Sciences);2008年06期
17 Xiao-Dong Zhang;Long-Jiang Zhang;Sheng-Yong Wu;Guang-Ming lu;;Multimodality magnetic resonance imaging in hepatic encephalopathy: An update[J];World Journal of Gastroenterology;2014年32期
18 Jun Xu;Rui Ma;Li-Feng Chen;Li-Jun Zhao;Kan Chen;Ren-Bing Zhang;;Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis:an updated meta-analysis of six randomized controlled trials[J];Hepatobiliary & Pancreatic Diseases International;2014年04期
19 ;Risk factors for sepsis-associated encephalopathy[J];Neural Regeneration Research;2011年04期
中国重要会议论文全文数据库 前20条
1 ;Recurrent Hashimoto' s encephalopathy,showing spontaneous remission:a case report[A];中华医学会第十次全国内分泌学学术会议论文汇编[C];2011年
2 Zheng Jiayin;Han Song;Luo Yanlin;Zhang Yunxia;Zhao Li;Li Junfa;;Identification of protein kinase C isoforms involved in type 1diabetic encephalopathy of mice[A];第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会论文集[C];2017年
3 ;Rifaximin Versus Non-absorbable Disaccharides in the Management of Hepatic Encephalopathy[A];2009香港-北京-杭州内科论坛暨2009年浙江省内科学学术年会论文汇编[C];2009年
4 王亚云;千年松;李俊杰;季茹;魏燕燕;杨雁灵;;Decreased expression of the potassium-chloride co-transporter KCC2 in cirrhotic patients with acute hepatic encephalopathy[A];中国解剖学会2011年年会论文文摘汇编[C];2011年
5 Chunyan Peng;Qianyun Ma;Yuzheng Zhuge;Xiaoping Zou;;The diagnostic value of critical flicker frequency in patients with minimal hepatic encephalopathy:A prospective study[A];2012中国消化系疾病学术大会论文汇编[C];2012年
6 Rui-Zhang Han;Jia-Hui Huang;Lei Xie;Yuan Qiao;Xin-Min Lu;Jiang-Chen Peng;Jin-Jia Hu;;The role of PAF receptor antagonist on the protection against radiation encephalopathy[A];中国解剖学会2013年年会论文文摘汇编[C];2013年
7 ;Demyelinating encephalopathy in patients following allogeneic hematopoietic stem cell transplantation:a retrospective analysis of incidence,risk factors and survival[A];第13届全国实验血液学会议论文摘要[C];2011年
8 徐春生;李传富;王辉;汪瀚;;A case of Hashimoto's encephalopathy with White Matter Widely Involved[A];中国中西医结合学会医学影像专业委员会第十五次全国学术大会暨上海市中西医结合学会医学影像专业委员会2017年学术年会暨《医学影像新技术的临床应用》国家级继续教育学习班资料汇编[C];2017年
9 李康生;王革非;李卫中;;流感急性脑病(英文)[A];新发和再发传染病防治热点研讨会论文集[C];2010年
10 项静燕;陈静炯;赵玉武;耿直;;产后可逆性后部脑病综合征2例及临床分析[A];中华医学会第十八次全国神经病学学术会议论文汇编(上)[C];2015年
11 Yan-Xin Tan;Ruo-Lan Du;Lu-Lu Xue;Ting-Hua Wang;Yan-Bing Xi-Yang;Liu-Lin Xiong;;Vof-16 silencing improves the recovery in neonatal hypoxic-ischemic encephalopathy of rats[A];中国解剖学会2019年年会论文文摘汇编[C];2019年
12 隋敏生;;急性一氧化碳中毒后迟发性脑病的临床分析[A];中华医学会急诊医学分会第十三次全国急诊医学学术年会大会论文集[C];2010年
13 Xiao-Lan WANG;Zhi-Hua YANG;Guang-Pin CHU;Xian-Fang MENG;;Protection of neurons from hyperglycemia-induced injury by deletion of MAD2B[A];中国神经科学学会第十届全国学术会议论文摘要集[C];2013年
14 ;Time course and evaluation of neurological deficits after focal cerebral ischemia in mice[A];第十一届全国神经药理学术会议论文摘要集[C];2004年
15 Zheng Zou;Pengyu Pan;Dongdong Liu;Gen Li;Guangzhi Hao;Xu Gao;Hua feng;Yushu Dong;Guobiao Liang;;MAP4K4 Induced Rapid Blood-Brain Barrier Damage after Subarachnoid Hemorrhage in Mice[A];第十四届中国医师协会神经外科医师年会摘要集[C];2019年
16 陈伏祥;;Necrostatin-1 Attenuates Secondary Brain Injury After Intracerebral Hemorrhage by Inhibiting the Necroptosis Signaling Pathway[A];第十四届中国医师协会神经外科医师年会摘要集[C];2019年
17 ;Netrin-1 hyper-expression of in the brain promotes angiogenesis and improves neurological outcome in transient MCAO mice[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
18 蔡晔雨;;The MRI findings of Mitochondrial Encephalopathy[A];中国中西医结合学会医学影像专业委员会第十五次全国学术大会暨上海市中西医结合学会医学影像专业委员会2017年学术年会暨《医学影像新技术的临床应用》国家级继续教育学习班资料汇编[C];2017年
19 吴学勤;;儿童可逆性后部脑病综合征4例报道并文献回顾[A];第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会论文汇编[C];2016年
20 ;Human embryonic neural stem cell transplantation attenuates apoptosis in the penumbra and improves neurological functions after focal cerebral ischemia in adult rats[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年
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1 Deepak Bagale;[D];重庆医科大学;2014年
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