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Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease

Shane V.Hegarty  Aideen M.Sullivan  Gerard W.O’Keeffe  
【摘要】:正Introduction:Parkinson’s disease(PD)is a chronic,age-related neurodegenerative disorder that affects 1–2%of the population over the age of 65.PD is characterised by the progressive degeneration of nigrostriatal dopaminergic(DA)neurons.This leads to disabling motor symptoms,due to the striatal DA denervation.Despite decades of research,

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