收藏本站
收藏 | 投稿 | 手机打开
二维码
手机客户端打开本文

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease

Shane V.Hegarty  Gerard W.O’Keeffe  Aideen M.Sullivan  
【摘要】:Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 ;Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological function[J];第二军医大学学报;2005年07期
2 ;Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?[J];Neural Regeneration Research;2010年17期
3 陈哲宇 ,李建红 ,郑兴东 ,路长林 ,何成;Effect of glial cell line-derived neurotrophic factor on peripheral nerve regeneration in adult rat[J];Journal of Medical Colleges of PLA;2001年03期
4 鲁凯伍,陈哲宇,侯铁胜;Protective effect of liposome-mediated glial cell line-derived neurotrophic factor gene transfer in vivo on motoneurons following spinal cord injury in rats[J];Chinese Journal of Traumatology;2004年05期
5 黄涛,姜晓丹,许忠,袁军,丁涟沭,邹雨汐,徐如祥;Construction of eukaryotic expression vector with brain-derived neurotrophic factor receptor trkB gene[J];Chinese Journal of Traumatology;2005年03期
6 胡德志,周良辅,朱剑虹,毛颖,吴雪海;Upregulated gene expression of local brain-derived neurotrophic factor and nerve growth factor after intracisternal administration of marrow stromal cells in rats with traumatic brain injury[J];Chinese Journal of Traumatology;2005年01期
7 ;Glial cell-derived neurotrophic factor mRNA expression in a rat model of spinal cord injury following bone marrow stromal cell transplantation[J];Neural Regeneration Research;2008年10期
8 ;Inhibition of ciliary neurotrophic factor in a rat model of transected spinal cord[J];Neural Regeneration Research;2011年02期
9 ;Brain-derived neurotrophic factor and neural plasticity in a rat model of spinal cord transection[J];Neural Regeneration Research;2011年13期
10 ;Adenovirus-mediated human brain-derived neurotrophic factor gene-modified bone marrow mesenchymal stem cell transplantation for spinal cord injury[J];Neural Regeneration Research;2011年16期
11 ;Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer's disease[J];Neural Regeneration Research;2012年04期
12 Hongyan Wang;Yingquan Zhang;Mingqi Qiao;;Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder[J];Neural Regeneration Research;2013年09期
13 Jixiang Ren;Xiangyu Zhou;Jian Wang;Jianjun Zhao;Pengguo Zhang;;Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression[J];Neural Regeneration Research;2013年22期
14 李立新,徐启武,吴幼章,胡卫星,顾培元,傅震;Combined therapy of methylprednisolone and brain-derived neurotrophic factor promotes axonal regeneration and functional recovery after spinal cord injury in rats[J];Chinese Medical Journal;2003年03期
15 ;Cognitive disorder and changes in cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury[J];Neural Regeneration Research;2008年03期
16 ;A combination of chondroitinase ABC,glial cell line-derived neurotrophic factor,and Nogo A antibody delayed-release microspheres for the treatment of spinal cord injury[J];Neural Regeneration Research;2011年10期
17 ;Construction of a three-dimensional bionic nerve conduit containing two neurotrophic factors with separate delivery systems for the repair of sciatic nerve defects[J];Neural Regeneration Research;2011年13期
18 Ning Tian;Zeyuan Cao;Yan Zhang;;MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease[J];Neuroscience Bulletin;2014年02期
19 操军;;Plasma level of brain-derived neurotrophic factor and the related analysis in depressive patients with suicide attempt[J];China Medical Abstracts(Internal Medicine);2014年01期
20 ;The effects of ciliary neurotrophic factor on neurological function and glial activity following contusive spinal cord injury in the rats[J];第二军医大学学报;2004年05期
中国重要会议论文全文数据库 前10条
1 ;Effect of intermittent hypoxia on the expression of brain-derived neurotrophic factor in mouse[A];Proceedings of the 7th Biennial Meeting and the 5th Congress of the Chinese Society for Neuroscience[C];2007年
2 ;Glial cell line-derived neurotrophic factor-regulated palmitoylation of the neural cell adhesion molecule determines neuritogenesis[A];中国解剖学会2012年年会论文文摘汇编[C];2012年
3 ;SCIRRIO exerts its neurotrophic activity through thyrotropin releasing hormone receptor 2[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
4 ;Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by extracellularα-synuclein[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年
5 ;Effects of cornel iridoid glycoside on expression of brain derived neurotrophic factor and its receptor TrkB in focal cerebral ischemic rats[A];Proceedings of the 8th Biennial Conference of the Chinese Society for Neuroscience[C];2009年
6 ;Role of PI3-K/Akt pathway and its effect on glial cell line-derived neurotrophic factor in midbrain dopamine cells1[A];Proceedings of the 7th Biennial Meeting and the 5th Congress of the Chinese Society for Neuroscience[C];2007年
7 Robert K.McNamara;;Docosahexaenoic Acid Deficiency and Prefrontal Cortex Neuropathology in Recurrent Mood Disorders:Emerging Evidence from Magnetic Resonance Imaging Studies[A];中华医学会病理学分会2010年学术年会日程及论文汇编[C];2010年
8 Hong Jin;Qin Wei;Long Chen;Qin Sun;Naifeng Liu;Genshan Ma;;The association between physical activity and plasma BDNF levels in patients with coronary artery disease[A];中国微循环学会2014年全国学术会议大会汇编[C];2014年
9 Xin-chen Wang;Du-juan Xu;;Association study of BDNF、6DNF gene polymorphism with plasma drug concentration and efficacy of paroxetine in major depressive patients[A];安徽省药理学会2012年学术年会论文汇编[C];2012年
10 Vijay Pandey;Peter E.Lobie;;Neurotrophic Factor Artemin as a Novel Therapeutic Target in Oncology[A];2008年全国生物化学与分子生物学学术大会论文摘要[C];2008年
中国博士学位论文全文数据库 前1条
1 Elkhalifa Mahjoub Elkhalifa Ahmed;植入羊膜上皮细胞的化学去细胞肌肉组织工程支架对大鼠脊髓损伤的修复机制[D];吉林大学;2013年
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978