收藏本站
收藏 | 投稿 | 手机打开
二维码
手机客户端打开本文

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Jiahui He  Zixi Zhang  Yutong Yang  Fenggang Ren  Jipeng Li  Shaojun Zhu  Feng Ma  Rongqian Wu  Yi Lv  Gang He  Baolin Guo  Dake Chu  
【摘要】:Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS) were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type Ⅰ collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.

知网文化
【相似文献】
中国期刊全文数据库 前16条
1 Yongsan Li;Xing Wang;Yen Wei;Lei Tao;;Chitosan-based self-healing hydrogel for bioapplications[J];Chinese Chemical Letters;2017年11期
2 Guiting Liu;Ziting Bao;Jun Wu;;Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing[J];Chinese Chemical Letters;2020年07期
3 Li-Jun Wang;Kai-Xiang Yang;Qiang Zhou;Hai-Yang Yang;Jia-Qing He;Xing-Yuan Zhang;;Rhodamine Mechanophore Functionalized Mechanochromic Double Network Hydrogels with High Sensitivity to Stress[J];Chinese Journal of Polymer Science;2020年01期
4 Wei Liang;Zhongkuan Luo;Li Zhou;;Preparation and characterization of the n-HA/PVA/CS porous composite hydrogel☆[J];Chinese Journal of Chemical Engineering;2020年02期
5 Yibin Yu;Ruoxi Feng;Jinyu Li;Yuanyuan Wang;Yiming Song;Guoxin Tan;Dandan Liu;Wei Liu;Xinggang Yang;Hao Pan;Sanming Li;;A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform[J];Asian Journal of Pharmaceutical Sciences;2019年04期
6 Xing-Quan Wang;Qing-Sheng Yang;;A general solution for one dimensional chemo-mechanical coupled hydrogel rod[J];Acta Mechanica Sinica;2018年02期
7 张凌溪;陈亦凡;徐海星;BAO Yun;YAN Xiumei;LI Yixuan;LI Yiping;YIN Yixia;WANG Xinyu;QIU Tong;HUANG Zhijun;XU Peihu;WANG Xiaobing;;Preparation and Evaluation of an Injectable Chitosan-Hyaluronic Acid hydrogel for Peripheral Nerve Regeneration[J];Journal of Wuhan University of Technology(Materials Science);2016年06期
8 Gopinathan Janarthanan;Insup Noh;;Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications[J];Journal of Materials Science & Technology;2021年04期
9 张骞骞;陈良;周小军;秦明;苗莹珂;何创龙;;In situ Crosslinked Hydrogel as Drug Carrier for Promoting Angiogenesis[J];Journal of Donghua University(English Edition);2017年01期
10 Mei Yuan;Xiaojie Ju;Rui Xie;Wei Wang;Liangyin Chu;;Micromechanical properties of poly(N-isopropylacrylamide)hydrogel microspheres determined using a simple method[J];Particuology;2015年02期
11 李岳南;海苗苗;赵宇;吕亚蕾;何益;陈果;刘雳宇;刘如川;Guigen Zhang;;Controlled generation of cell–laden hydrogel microspheres with core–shell scaffold mimicking microenvironment of tumor[J];Chinese Physics B;2018年12期
12 张尚文;HAN Dandan;DING Zongxian;WANG Xin;ZHAO Dan;胡燕;XIAO Xincai;;Fabrication and Characterization of One Interpenetrating Network Hydrogel Based on Sodium Alginate and Polyvinyl Alcohol[J];Journal of Wuhan University of Technology(Materials Science);2019年03期
13 ZiHe Guo;Tao Ma;ShiYu Fu;;Preparation of Photo-thermal Cellulose Nanocrystal-based Hydrogel[J];Paper and Biomaterials;2019年02期
14 ;A novel positively thermo-sensitive hydrogel based on ethylenediaminetetraacetic dianhydride and piperazine:Design,synthesis and characterization[J];Chinese Chemical Letters;2012年01期
15 Guanru Chang;Shikuo Li;Fangzhi Huang;Xiuzhen Zhang;Yuhua Shen;Anjian Xie;;Multifunctional Reduced Graphene Oxide Hydrogel as Drug Carrier for Localized and Synergic Photothermal/Photodynamics/Chemo Therapy[J];Journal of Materials Science & Technology;2016年08期
16 Hao Li;Youzeng Li;Qun Xu;Ali Zhang;;Multifunctional Clay/PNIPAM Hydrogel Incorporating H_xMoO_3 Plasmonic Quantum Dot[J];Energy & Environmental Materials;2020年02期
中国重要会议论文全文数据库 前11条
1 Zhimei Lei;Jie Liu;Yu Chen;孙贺略;Haitao Yu;;Glucosactone Fueled Hydrogel Constructed via Urea Derived Alanine[A];中国化学会·第十六届全国有机合成化学学术研讨会论文摘要集[C];2019年
2 吴宝意;张佳玮;陈涛;;智能水凝胶驱动器的制备与应用[A];中国化学会第十七届全国胶体与界面化学学术会议论文(摘要)集(第二卷)[C];2019年
3 陈明月;付纪军;;Prussian blue nanospheres embedded in-situ hydrogel for photothermal therapy by peritumoral administration[A];2018年第十二届中国药物制剂大会论文集[C];2018年
4 Dongjian SHI;Fei WANG;Rongjin LIU;Mingqing CHEN;;Studies on Synthesis of DOPA-Based Polymer Hydrogels and Their Self-Healing Properties[A];第二届海峡两岸功能材料科技与产业峰会(2015)摘要集[C];2015年
5 Yang Zhou;Liren Fan;Jiqing Song;Wenbo Bai;Qin Peng;Ming Zeng;Haifeng Li;;Water Absorbency and Phosphorus Release Properties of hybrid Hydrogel Fertilizers Embedding Activated Phosphate Rock Powder[A];中国颗粒学会超微颗粒专委会2013年年会暨第八届海峡两岸超微颗粒学术研讨会论文集[C];2013年
6 Lei Zhang;Lin Liu;Jianping Lei;Huangxian Ju;;Self-assembled DNA hydrogel as switchable material for aptamer-based fluorescent detection of protein[A];第八届全国化学生物学学术会议论文摘要集[C];2013年
7 田文学;Jialing Dai;Shangcong Han;Yong Sun;;Co-delivery of Hydrophilic/hydrophobic Drugs by Thermo-sensitive Hydrogel as Microbicides[A];2018年第十二届中国药物制剂大会论文集[C];2018年
8 ;Hydrogel: A Key Material for Life Science[A];2005年全国高分子学术论文报告会论文摘要集[C];2005年
9 程义云;胡婧婧;;Aminoglycoside Hydrogels[A];2018(第3届)抗菌科学与技术论坛论文摘要集[C];2018年
10 苏君庆;Wei Qu;Bo Yang;ZhenHeng Wang;;Preparation and characterization of recombinant human basic fibroblast growth factor niosomal gel for ophthalmic delivery[A];2018年第十二届中国药物制剂大会论文集[C];2018年
11 Yahui Ma;Fei Wang;Tongchun Bai;;The Physical Chemistry Properties of the Polyvinylalcohol/Polyvinylpyrrolidone/Hydroxyapatite Composite Hydrogel for Articular Cartilage Repairing[A];中国化学会第五届全国热分析动力学与热动力学学术会议论文摘要集[C];2015年
中国博士学位论文全文数据库 前2条
1 汤柳燕;可自修复席夫碱类金属络合水凝胶的制备与性能[D];华南理工大学;2019年
2 廖美红;功能性水凝胶的性能调控及其在柔性传感器的应用研究[D];北京化工大学;2020年
中国硕士学位论文全文数据库 前6条
1 Ali Raza Khan;[D];华东理工大学;2020年
2 赵慧男;辐射制双氯芬酸钠水凝胶经皮给药制剂的研究[D];第一军医大学;2005年
3 张佳星;多重刺激响应型水凝胶的制备及其应用[D];上海工程技术大学;2020年
4 黄兴华;丙烯酰胺类水凝胶的溶胀特性及其在生物技术中的应用研究[D];福州大学;2004年
5 靳凯运;功能化快速自愈合水凝胶的制备及其研究[D];长春工业大学;2020年
6 廖珊珊;多功能自修复席夫碱类高分子水凝胶的制备与性能[D];华南理工大学;2020年
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978