收藏 | 投稿 | 手机打开

Circulating immune parameters-based nomogram for predicting malignancy in laryngeal neoplasm

Min Chen  Yi Fang  Yue Yang  Pei-Jie He  Lei Cheng  Hai-Tao Wu  
【摘要】:BACKGROUND Malignancy prediction remains important to preoperative diagnosis and postoperative follow-up in laryngeal neoplasm.AIM To evaluate the circulating immune population and develop a nomogram for prediction of malignancy in patients with laryngeal neoplasm.METHODS A primary cohort of 156 patients was divided into laryngeal benign lesion, premalignant lesion and malignant lesion groups. Peripheral blood from patients was measured by blood routine test and flow cytometry. A nomogram was developed and applied to a validation cohort containing 55 consecutive patients.RESULTS Age, gender and seven circulating immune parameters exhibited significant differences between laryngeal benign lesion and premalignant lesion. The nomogram incorporated predictors, including gender, age, smoke index, proportions of monocytes, CD8+ T cells, CD4+ T cells, B cells and CD4/CD8+ T cell ratio. It showed good discrimination between laryngeal premalignant lesion and malignant lesion, with a C-index of 0.844 for the primary cohort. Application of this nomogram in the validation cohort(C-index, 0.804) still had good discrimination and good calibration. Decision curve analysis revealed that the nomogram was clinically useful.CONCLUSION This novel nomogram, incorporating both clinical risk factors and circulating immune parameters, could be appropriately applied in preoperative individualized prediction of malignancy in patients with laryngeal neoplasm.

中国期刊全文数据库 前19条
1 Yutong He;Di Liang;Daojuan Li;Baoen Shan;Rongshou Zheng;Siwei Zhang;Wenqiang Wei;Jie He;;Incidence and mortality of laryngeal cancer in China, 2015[J];Chinese Journal of Cancer Research;2020年01期
2 Kadri Altundag;Ting Jin;Pei-Jing Li;Xiao-Zhong Chen;Wei-Han Hu;;Immune evasion might affect survival in laryngeal cancer patients with blood group O[J];Chinese Journal of Cancer;2017年12期
3 Ting Jin;Pei-Jing Li;Xiao-Zhong Chen;Wei-Han Hu;;ABO blood group is a predictor of survival in patients with laryngeal cancer[J];Chinese Journal of Cancer;2016年12期
4 ;Study of the SH3-domain GRB2-1ike 2 gene expression in laryngeal carcinoma[J];Chinese Medical Journal;2007年05期
5 ;Discovery of laryngeal carcinoma by serum proteomic pattern analysis[J];Science in China(Series C:Life Sciences);2004年03期
6 杨蓓蓓,李福军;Quantitative analysis of TGF-α and EGFR mRNA in laryngeal carcinoma tissues[J];Chinese Medical Journal;1999年12期
7 Hao Wu;Yan-Fen Huang;Xiang-Hong Liu;Mei-Hua Xu;;Extrapancreatic solid pseudopapillary neoplasm followed by multiple metastases: Case report[J];World Journal of Gastrointestinal Oncology;2017年12期
8 Jin-Zhang Cheng;Dan Yu;Hui Zhang;Chun-Shun Jin;Yan Liu;Xue Zhao;Xin-Meng Qi;Xueshi-Bojie Liu;;Inhibitive effect of IL-24 gene on CD133~+ laryngeal cancer cells[J];Asian Pacific Journal of Tropical Medicine;2014年11期
9 Yinan Hua;Piyush Soni;Douglas Larsen;Riyam Zreik;Bing Leng;Debby Rampisela;;SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma mimicking solid pseudopapillary neoplasm: A case report and review of the literature[J];World Journal of Gastroenterology;2020年36期
10 ;Pancreas[J];China Medical Abstracts(Internal Medicine);2015年03期
11 ;Comparison of diagnostic accuracy between ~(18)F-FDG PET and PET/CT for pulmonary neoplasm[J];Nuclear Science and Techniques;2009年01期
12 ;Primary Osteosarcoma of the Breast in Young Women: One Case Report and Literature Review[J];Clinical Oncology and Cancer Research;2009年04期
13 陈洪茂,赵佐庆,吕发勤;Changes and significances of SOD and MDA after ischemia reperfusion injury of hepatic neoplasm[J];Journal of Medical Colleges of PLA;2003年03期
14 张得希;多原发性恶性肿瘤24例报告[J];临床荟萃;1996年13期
15 ;Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells[J];Acta Pharmacologica Sinica;2005年03期
16 耿娟;雷艳荣;裴圣广;;Correlation between Survivin Expression and Laryngeal Carcinoma:A Meta-analysis[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2017年06期
17 ;Primary Renal Angiosarcoma:One Case Report and Literatures Review[J];Chinese Journal of Clinical Oncology;2008年03期
18 Jung-Hee Yoon;;Primary renal carcinoid tumor: A rare cystic renal neoplasm[J];World Journal of Radiology;2013年08期
19 ;Primary malignant bone neoplasm:a case report of dedifferentiated chondrosarcoma in the rib and review of the literature[J];癌症;2010年11期
中国重要会议论文全文数据库 前20条
1 Li Shen;Qing Ke;Jingjing Chai;Chuanyi Zhang;Li Qiu;Feng Peng;Xinzhou Deng;Zhiguo Luo;;PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3[A];2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛论文集[C];2018年
2 Li Shen;Lu Meng;Yingying Wang;Qiwen Duan;Li Qiu;Feng Peng;Zhiguo Luo;Xiaoxia Dong;;Altered O-glycosylation is associated with inherent radioresistance and malignancy of human laryngeal carcinoma[A];2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛论文汇编[C];2017年
3 Xiao-Hong Wu;Su-Ping Chen;Jian-Ying Mao;Xue-Xian Ji;Hong-Tian Yao;Shui-Hong Zhou;;Expression and significance of hypoxia-inducible factor-1αand glucose transporter-lin laryngeal carcinoma[A];2012年浙江省耳鼻咽喉科学学术年会论文集[C];2012年
4 ;Advance of pathogenesy on laryngeal cancer[A];第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议教育集[C];2006年
5 ;Detection of Human Papillomavirus L1, -16 and and-18 DNA in laryngeal Carcinoma[A];第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议论文集[C];2006年
6 Qin,Nan;Cai,Shunfeng;Wang,Tingting;;The role of Gut Microbiome in the Response to cancer immunothera[A];2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛论文集[C];2019年
7 Minjie Wang;Jun Qi;Xuexiang Li;Baojun Wei;Chao Fu;Jia Gao;;The clinical value of HE4[A];中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议摘要集[C];2010年
8 Shen Li-Fang;Zhou Shui-Hong;Zhao Xin;Lu Zhong-Jie;Zhao Kui;Fan Jun;Zhou Min-Li;;In vivo evaluation of effect of simultaneous inhibition of GLUT-1 and HIF-1α by antisense oligodeoxynucleotides on radiosensitivity of laryngeal carcinoma using micro 18F-FDG PET/CT[A];2016年浙江省医学会耳鼻咽喉头颈外科学学术年会论文汇编[C];2016年
9 ;Expression of p63 isoforms in laryngeal squamous cell carcinomas[A];第二届中国医学细胞生物学学术大会暨细胞生物学教学改革会议论文集[C];2008年
10 ;Laryngeal Framework Reconstruction using Titanium Mesh in Glottic Cancer after Frontolateral Vertical Partial Laryngectomy[A];中华医学会肿瘤学分会第七届全国中青年肿瘤学术会议——中华医学会肿瘤学分会“中华肿瘤 明日之星”大型评选活动暨中青年委员全国遴选论文汇编[C];2011年
11 De-Sheng Shang;Ling-Xiang Ruan;Shui-Hong Zhou;Yang-Yang Bao;Ke-Jia Cheng;Qin-Ying Wang;;Differentiating laryngeal carcinomas from precursor lesions by diffusion-weighted magnetic resonance imaging at 3.0T:a preliminary study[A];2013年浙江省放射学学术年会论文集[C];2013年
12 胡海兵;;Yolk Sac Tumor Of Testicular In a Young Children:A Case Report[A];第十五届全国泌尿外科学术会议论文集[C];2008年
13 ;MicroRNAs for diagnosis of lymph node metastases from primary suproglottic laryngeal squamous cell carcinoma[A];中华医学会肿瘤学分会第七届全国中青年肿瘤学术会议——中华医学会肿瘤学分会“中华肿瘤 明日之星”大型评选活动暨中青年委员全国遴选论文汇编[C];2011年
14 胡海兵;;Yolk Sac Tumor In a Young Children:A Case Report[A];第十五届全国泌尿外科学术会议论文集[C];2008年
15 Shui-Hong Zhou;Yang-Yang Bao;Qin-Ying Wang;Kui Zhao;Ling-Xiang Ruan;Hong-Tian Yao;;Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma:use of PET/CT in follow-up[A];2012年浙江省耳鼻咽喉科学学术年会论文集[C];2012年
16 ;Angioleiomyomas in the Bilateral Broad Ligaments[A];2009年浙江省病理学学术年会论文汇编[C];2009年
17 Chi-qi Chen;Jian-bo Wu;Li-hui Yin;Hang-yi Xiang;Shen-meng Gao;;Methylated alteration of SHP1 complements mutation of JAK2 tyrosine kinase in Chinese patients with myeloproliferative neoplasm[A];2013年国家级“恶性血液系统疾病诊治新进展”学习班暨学术年会资料汇编[C];2013年
18 Zhisen Shen;Dong Ye;Hongxia Deng;Huaxin Ding;Xiaolei Ye;Guowen Zhan;Junming Guo;;The effect and mechanism of microRNA-519a mimic on the nude mouse xenograft model of laryngeal cancer[A];2014年浙江省医学会耳鼻咽喉头颈外科学学术年会论文汇编[C];2014年
19 Shui-Hong Zhou;Yang-Yang Bao;Qin-Ying Wang;Kui Zhao;Ling-Xiang Ruan;Hong-Tian Yao;;Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma:use of PET/CT in follow-up[A];全国耳鼻咽喉头颈外科中青年学术会议论文汇编[C];2012年
20 ;Inflammatory Myofibroblastic Tumor of The Rectum in Children:A Case Report[A];2011年浙江省小儿外科学术年会论文汇编[C];2011年
中国硕士学位论文全文数据库 前1条
1 程炜;233例母细胞性浆细胞样树突状细胞肿瘤系统性回顾[D];南昌大学;2019年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978