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Toosendanin-induced Ca~(2+) Conductance Increase in Neuroblastoma×Giioma Hybrid Cells

施玉樑  Furuya Kishio  王文萍  Terakawa Susumu  徐科  Yamagishi Shunichi  
【摘要】:正 Toosendanin (TSN), a triterpenoid derivative extracted from the bark of Melia toosendan Seib et Zucc and used in Chinese traditional medicine as an anthelmintic against ascaris, is a presynaptic neuromuscular blocker. Without affecting the nerve conduction, the muscle resting potential as well as acetylcholine (ACh) sensitivity of the muscle membrane at the end-plate region, TSN blocks the neuromuscular transmission selectively by inhibiting ACh release from the motor nerve terminals. It was interesting to notice that

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