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A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene

ZOU Yang  JIN Xin  ZHANG XiaoPing  KONG XiaoLing  ZHANG Qian  XIE XianHua  LIU ChangJun  KE LinNan  LIU WenGuang  WANG Wei  
【摘要】:Biomedical patches play fundamental roles in various applications such as wound closure and tissue regeneration. The hybrid patches integrating versatile properties will prominently improve the therapeutic effects in clinical applications. Herein, an epoxy network loading curcumin and Ti3 C2 TxMXenes were developed as a hybrid biomedical patch. The hybrid patch was basically prepared through an epoxy/thiol curing chemistry, and its topological structure can be destructed and rearranged as a vitrimer does due to the active transesterification at high temperature. The resulted hybrid patch exhibits shape-morphing capability,multi-substrate adhesion, self-healing ability, and photothermal effects under 980 nm near infrared(NIR). Additionally, the asprepared hybrid patch possesses strong UV-shielding, excellent oxidation resistance(ROS scavenging efficiency was 89.3% in3 min), highly effective antibacterial vitality(more than 99%) against S. aureus and E. coli, and good cytocompatibility. As a proof of concept, the present multifunctional hybrid patch broadens the potential applications in the biomedical field.

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