【摘要】：AIM: To evaluate the survival outcomes of patients with lacrimal gland adenoid cystic carcinoma who underwent eye-sparing surgery combined with ~(125)I seed implantation radiotherapy or local external γ-ray radiotherapy.METHODS: In this retrospective comparative case series, the clinical records of 27 primary and 8 recurrent patients were reviewed. Univariate and multivariate analyses were used to identify risk factors associated with distant metastasis(DM), and the overall survival(OS) after the initial surgery was analyzed.RESULTS: The median follow-up after radiotherapy was 36 mo(range 6-120 mo). At the last follow-up after radiotherapy, 26(74.3%) patients had no evidence of disease, 7(20%) patients had DM, 2(5.9%) patients died of DM, and 1 patient with DM was lost to follow-up. Univariate analyses showed that duration of symptoms, bone destruction, T stage classification, and wide excision surgery were risk factors influencing DM(P0.05). The 5-year and 10-year OS rates after the initial surgery were 95.8% and 79.9%, respectively. The 5-year DM-free survival and disease-free survival rates after radiotherapy were 66.4% and 52.7%, respectively.CONCLUSION: ~(125)I seed radiotherapy and local external γ-ray radiotherapy may have similar therapeutic effects in preventing DM. Patients with T1/T2 stage disease have a better prognosis than those with T3/T4 stage disease.