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The first catalytic asymmetric addition of diethylzinc to aldehyde promoted by chiral thiourea

【摘要】:正A series of C_2-symmetric and asymmetric chiral thiourea derivatives were synthesized from commercial L-phenylalanine.All of the new compounds have been fully characterized by IR,~1H NMR,~(13)C NMR,MS spectra and elemental analyses.The chiral thioureas were used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc,the corresponding sec-alcohols were gained with excellent enantioselectivities(up to 87.1%ee) and high yields(up to 76.7%) after the conditions were optimized.

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