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Convenient synthesis of chiral H_4-BINOL via direct hydrogenation of BINOL

【摘要】:正A simple,highly effective hydrogenation of chiral BINOL to provide H_4-BINOL in multigram scale with good yield(up to 78% yield) was developed.A series of heterogeneous catalysts was tested in the hydrogenation;;the best result was obtained with 5%Pd/ C in EtOH under the H_2 pressure of 50 bar for 2 h.This method is a more useful method for practical synthesis of optically pure H_4- BINOL than other available methods.

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