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Synthesis and antitumor activity of 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones

【摘要】: <正>Sixteen novel 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their cytotoxicities were evaluated in vitro against BEL-7402,HT-29 and SPC-A1 cell lines.The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line.Compound lab exhibited the most potent antitumor activity among the tested compounds.

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