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New synthetic way to prepare 2-aryl-8-(piperidin-4-yl)-5,7-dimethoxy-4H-chromen-4-one as key intermediate for CDK inhibitor

【摘要】: <正>As an important intermediate to study cyclin-dependent kinase(CDK)inhibitors,2-aryl-8-(piperidin-4-yl)-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared usingβ-diketone route with low yield.In our study,chalcone route has been investigated and the result suggested that the benzaldehydes substituted with electron-donating group give much better yield thanβ-diketone route.This new method will be an efficient way to start further research on new anticancer flavonoids.

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