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M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy

Wenshen Wang  Fenfen Li  Shibo Li  Yi Hu  Mengran Xu  Yuanyuan Zhang  Muhammad Imran Khan  Shaozhen Wang  Min Wu  Weiping Ding  Bensheng Qiu  
【摘要】:Tumor-associated macrophages(TAMs) play an important role in tumor development and progression.In particular,M2 TAMs can promote tumor growth by facilitating tumor progression and malignant behaviors.Selectively targeted elimination of M2 TAMs to inhibit tumor progression is of great significance for cancer treatment.Iron oxide nanoparticles based magnetic hyperthermia therapy(MHT) is a classical approach to destroy tumor tissue with deep penetration depth.In this study,we developed a typical M2 macrophage-targeted peptide(M2pep) functionalized superparamagnetic iron oxide nanoparticle(SPIO) for magnetic resonance imaging(MRI)-guided MHT in an orthotopic breast cancer mouse model.The obtained multifunctional SPIO-M2 pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability,high transverse relaxivity(149 m M~(-1)s~(-1)) and satisfactory magnetic hyperthermia performance in vitro.In vivo studies demonstrated that the SPIO-M2 pep based MRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for MHT.The M2 macrophage-targeted MHT significantly reduced the tumor volume and the population of pro-tumoral M2 TAMs in tumor.In addition,the SPIO-M2 pep based MHT can remodel the tumor immune microenvironment(TIME).The multifunctional SPIO-M2 pep with M2 macrophage-targeting ability,high magnetic hyperthermia efficiency,MR imaging capability and effective role in remodeling the TIME hold great potential to improve clinical cancer therapy outcomes.

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中国期刊全文数据库 前1条
1 Xi Huang;Yanlong Yin;Min Wu;Wang Zan;Qian Yang;;LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia[J];Chinese Chemical Letters;2019年06期
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