收藏本站
收藏 | 投稿 | 手机打开
二维码
手机客户端打开本文

The role of serratiopeptidase in the resolution of inflammation

Manju Tiwari  
【摘要】:Inflammation remains a key event during most of the diseases and physiological imbalance. Acute inflammation is an essential physiological event by immune system for a protective measure to remove cause of inflammation and failure of resolution lead to chronic inflammation. Over a period of time, a number of drugs mostly chemical have been deployed to combat acute and chronic inflammation. Recently, enzyme based anti-inflammatory drugs became popular over conventional chemical based drugs. Serratiopeptidase, a proteolytic enzyme from trypsin family, possesses tremendous scope in combating inflammation. Serine protease possesses a higher affinity for cyclooxygenase(COX-Ⅰ and COX-Ⅱ), a key enzyme associated with production of different inflammatory mediators including interleukins(IL),prostaglandins(PGs) and thromboxane(TXs) etc. Currently, arthritis, sinusitis, bronchitis,fibrocystic breast disease, and carpal tunnel syndrome, etc. are the leading inflammatory disorders that affected the entire the globe. In order to conquer inflammation, both acute and chronic world, physician mostly relies on conventional drugs. The most common drugs to combat acute inflammation are Nonsteroidal anti-inflammatory drugs(NSAIDs) alone and or in combination with other drugs. However, during chronic inflammation, NSAIDs are often used with steroidal drugs such as autoimmune disorders. These drugs possess several limitations such as side effects, ADR, etc. In order to overcome these limitations and complications, enzyme based drugs(anti-inflammatory) emerged, and aim for a new high since the last decade. Serine protease, the largest proteolytic family has been reported for several therapeutic applications, including anti-inflammatory. Serratiopeptidase is a leading enzyme which has a very long history in medical as an effective anti-inflammatory drug. Current study emphasizes present scenario and future prospect of serratiopeptidase as an antiinflammatory drug. The study also illustrates a comparative analysis of conventional drugs and enzyme based therapeutic to combat inflammation.

知网文化
【相似文献】
中国期刊全文数据库 前20条
1 Manju Tiwari;;The role of serratiopeptidase in the resolution of inflammation[J];Asian Journal of Pharmaceutical Sciences;2017年03期
2 Jiangjiang QIN;Wei WANG;Ruiwen ZHANG;;Novel natural product therapeutics targeting both inflammation and cancer[J];Chinese Journal of Natural Medicines;2017年06期
3 Manjir Sarma Kataki;Bibhuti B Kakoti;Biman Bhuyan;Ananya Rajkumari;Prakash Rajak;;Garden rue inhibits the arachidonic acid pathway, scavenges free radicals, and elevates FRAP: role in inflammation[J];Chinese Journal of Natural Medicines;2014年03期
4 Kai Jin;Zimiao Luo;Bo Zhang;Zhiqing Pang;;Biomimetic nanoparticles for inflammation targeting[J];Acta Pharmaceutica Sinica B;2018年01期
5 WANG Yun-jie;RUAN Wen-chen;XU Ya-zhou;ZHANG Lu-yong;PANG Tao;;Natural product compound 3c ameliorates brain inflammation and brain ischemic stroke via AMPK-mediated microglia polarization[J];中国药理学与毒理学杂志;2016年10期
6 Shoujin Dong;Yunqing Zhong;Kun Yang;Xiaoling Xiong;Bing Mao;;Intervention effect and dose-dependent response of Tanreqing injection on airway inflammation in lipopolysaccharide-induced rats[J];Journal of Traditional Chinese Medicine;2013年04期
7 MA Chun-Hua;LIU Ji-Ping;QU Rong;MA Shi-Ping;;Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice[J];Chinese Journal of Natural Medicines;2014年11期
8 ZHANG Tian-Zhu;YANG Shi-Hai;YAO Jin-Fu;DU Juan;YAN Tian-hua;;Sangxingtang inhibits the inflammation of LPS-induced acute lung injury in mice by down-regulating the MAPK/NF-κB pathway[J];Chinese Journal of Natural Medicines;2015年12期
9 YANG Ying-Lin;CHENG Xiao;LI Wei-Han;LIU Man;王月华;杜冠华;;KAE Alleviates LPS-induced Neuroinflammation in the Striatum of Mice via Down-regulating TLR4/MyD88 Signaling Pathway[J];神经药理学报;2018年02期
10 Wei-qiang LU;Jing-yuan WANG;Xue YAO;Ping OUYANG;Ning-ning DONG;Dang WU;Jin HUANG;;Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene a4 hydrolase and blocking LTB4 biosynthesis[J];中国药理学与毒理学杂志;2017年10期
11 YANG Jiang-Lin;WANG Jun-Lian;HUANG Fang;LIU Kang;LIU Bao-Lin;;Modified Si-Miao-San inhibits inflammation and promotes glucose disposal in adipocytes through regulation of AMP-kinase[J];Chinese Journal of Natural Medicines;2014年12期
12 SHANG Shu-Wan;YANG Jiang-Lin;HUANG Fang;LIU Kang;LIU Bao-Lin;;Modified Si-Miao-San ameliorates pancreatic B cell dysfunction by inhibition of reactive oxygen species-associated inflammation through AMP-kinase activation[J];Chinese Journal of Natural Medicines;2014年05期
13 ;Preliminary study on anti-inflammation of diclofenac arginine[J];延边医学院学报;1995年01期
14 Seyedeh Farnaz Ghasemi-Niri;Faheem Maqbool;Maryam Baeeri;Mahdi Gholami;Mohammad Abdollahi;;Phosalone-induced inflammation and oxidative stress in the colon: evaluation and treatment[J];World Journal of Gastroenterology;2016年21期
15 ;Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats[J];Acta Pharmacologica Sinica;2007年06期
16 Jain Smita;Patil U.K.;;Effect of Ipomea carnea Jacq. flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats[J];Chinese Journal of Natural Medicines;2014年03期
17 Esmail Abolghasemi;Seyed Hassan Moosa-Kazemi;Maryam Davoudi;Ahmad Reisi;Mohammad Taghi Satvat;;Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis[J];Asian Pacific Journal of Tropical Biomedicine;2012年04期
18 ;Inhibitory effect of acetamide-45 on airway inflammation and phosphodiesterase 4 in allergic rats[J];Acta Pharmacologica Sinica;2005年12期
19 M.Choi;JY.Baek;I.Park;SY.Lim;;Moderating effect of synthesized docosahexaenoic acid-enriched phosphatidylcholine on production of Th1 and Th2 cytokine in lipopolysaccharide-induced inflammation[J];Asian Pacific Journal of Tropical Biomedicine;2018年07期
20 SUR Tapas Kumar;BISWAS Tuhin Kanti;ALI Liaquat;MUKHERJEE Biswapati;;人胎盘提取液的抗炎和抗血小板聚集作用[J];Acta Pharmacologica Sinica;2003年02期
中国重要会议论文全文数据库 前10条
1 Hu Meng;Christopher L.McClendon;Ziwei Dai;Kenan Li;Ying Liu;Luhua Lai;;Discovery of 15-Lipoxygenase Activators as for Anti-inflammation Therapy[A];第八届全国化学生物学学术会议论文摘要集[C];2013年
2 ;Optimization of EP4 receptor antagonists:search for safer therapeutic agents to treat pain and inflammation[A];2011年全国药物化学学术会议——药物的源头创新论文摘要集[C];2011年
3 侯琦;;Study of Compound AH on anti-inflammation and mechanism[A];中国药理学会第九届制药工业药理学术会议论文摘要汇编[C];2000年
4 ;Network-based Drug Design Study on the Arachidonic Acid Metabolic Network[A];第六届全国化学生物学学术会议论文摘要集[C];2009年
5 Erchang Shang;Pei Liu;Xinyi Chen;Ying Liu;Luhua Lai;;Dual-functional Inhibitor Design for Cycloxygenase-2 and Leukotriene A4 Hydrolase[A];第八届全国化学生物学学术会议论文摘要集[C];2013年
6 ;Effects of hydrocortisone on the contents of monoamines and their metabolites in rat brains[A];中国药理学会第十次全国学术会议专刊[C];2009年
7 ;The Molecular Pathway of Glucocorticoids Mediated Neutrophil Delayed Apopotosis[A];第十一届全国中西医结合肾脏病学术会议论文汇编[C];2010年
8 Weiqiang Lu;Xue Zhao;Jin Huang;;Development of Novel Assay for the Determination of Lipoxygenases Activity[A];第八届全国化学生物学学术会议论文摘要集[C];2013年
9 Weirong Wang;Ling Bai;Hu Qiao;Yanxiang Li;Lina Yang;Jiye Zhang;Rong Lin;Feng Ren;Jianfeng Zhang;Meixi Ji;;PPARa Activation Inhibits Inflammatory Response in Endothelial Cells via the SIRT1-dependent Signaling Pathway[A];第十一届全国博士生学术年会(生物医药专题)论文集(中册,墙报P1-P24)[C];2013年
10 Bo Chen;Hongbin Sun;;A new synthetic access to topical corticosteroid anti-inflammatory agent difluprednate[A];2012长三角药物化学研讨会论文集[C];2012年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978