《World Journal of Gastroenterology》2008年19期 加入收藏    获取最新 
 Is infliximab safe to use while breastfeeding?
 Joel Z Stengel;Hays L ArnoldJ
 　　Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients.
【作者单位】：Brooke Army Medical Cente3851 Roger Brooke Drive;Brooke Army Medical Cente3851 Roger Brooke Drive Fort Sam Houston;TX 78234;United States;Fort Sam Houston;TX 78234;United States
【分类号】：R574
【DOI】：CNKI:SUN:ZXXY.0.2008-19-023
【正文快照】：
　　INTRODUCTION In recent years, targeted monoclonal antibodies and other biologic agents have been at the forefront of the numerous therapeutic options available to treat many immune- mediated disorders. A large number of young and fertile patients are affl…
 
 推荐 CAJ下载           PDF下载
 CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式
 Is infliximab safe to use while breastfeeding?
 Joel Z Stengel;Hays L Arnold;Brooke Army Medical Center;3851 Roger Brooke Drive;Fort Sam Houston;TX 78234;United States
 　Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients.
【Keyword】：Inflammatory bowel disease;Ulcerative colitis;Crohn’s disease;Pregnancy;Breast-feeding;Monoclonal antibodies