| | | | | Chronic intestinal pseudo-obstruction | | | Alexandra Antonucci;Lucia Fronzoni;Laura Cogliandro;Rosanna F Cogliandro;Carla Caputo;Roberto De Giorgio;Francesca Pallotti;Giovanni Barbara;Roberto Corinaldesi;Vincenzo Stanghellini | | | Chronic intestinal pseudo-obstruction (CIPO) is a se- vere digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one of the main causes of intestinal failure and is characterized by high morbidity and mortality. It may be idiopathic or secondary to a variety of diseases. Most cases are sporadic, even though familial forms with either dominant or recessive autosomal inheritance have been described. Based on histological features in- testinal pseudo-obstruction can be classified into three main categories:neuropathies, mesenchymopathies, and myopathies, according on the predominant involvement of enteric neurones, interstitial cells of Cajal or smooth muscle cells, respectively. Treatment of intestinal pseu- do-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases.
【作者单位】：Department of Internal Medicine and Gastroenterology University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Department of Internal Medicine and Gastroenterology;University of Bologna;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy;Bologna I-40138;Italy
【分类号】：R574
【DOI】：CNKI:SUN:ZXXY.0.2008-19-001
【正文快照】：
INTRODUCTION Chronic intestinal pseudo-obstruction (CIPO) is a rare, severe disease characterized by the failure of the intesti- nal tract to propel its contents which results in a clinical picture mimicking mechanical obstruction in the absence of any le… | | |
| | |  推荐 CAJ下载  PDF下载 | | | CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式 | | | | Chronic intestinal pseudo-obstruction | | | Alexandra Antonucci;Lucia Fronzoni;Laura Cogliandro;Rosanna F Cogliandro;Carla Caputo;Roberto De Giorgio;Francesca Pallotti;Giovanni Barbara;Roberto Corinaldesi;Vincenzo Stanghellini;Department of Internal Medicine and Gastroenterology;University of Bologna;Bologna I-40138;Italy | | | Chronic intestinal pseudo-obstruction (CIPO) is a se- vere digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one of the main causes of intestinal failure and is characterized by high morbidity and mortality. It may be idiopathic or secondary to a variety of diseases. Most cases are sporadic, even though familial forms with either dominant or recessive autosomal inheritance have been described. Based on histological features in- testinal pseudo-obstruction can be classified into three main categories:neuropathies, mesenchymopathies, and myopathies, according on the predominant involvement of enteric neurones, interstitial cells of Cajal or smooth muscle cells, respectively. Treatment of intestinal pseu- do-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases.
【Keyword】：Chronic intestinal pseudo-obstruction;Small bowel manometry;Immunohistochemistry;Prokinetics;Intestinal transplantation |
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