收藏本站
《Asian Pacific Journal of Tropical Medicine》 2015年04期
收藏 | 投稿 | 手机打开
二维码
手机客户端打开本文

Pharmacokinetic and pharmacodynamic analysis of ferulic acidpuerarin-astragaloside in combination with neuroprotective in cerebral ischemia/reperfusion injury in rats

Li-Jun Ge  Shou-Yan Fan  Jie-Hong Yang  Yi Wei  Zhen-Hong Zhu  Yi-Jia Lou  Ying Guo  Hai-Tong Wan  Yi-Qiang Xie  
【摘要】:Objective:To investigate the effects of the active ingredients combined therapy on inflammatory factors interleukin 1 beta(IL-1β)and neuropeptide Y(NPY)based on pharmacodynamics in rats.Methods:The animal model was built by transient middle cerebral artery occlusion(MCAO).The method for evaluating the concentrations of the FA-Pr-AI components in rat plasma was established by using HPLC and the expression levels of IL-1βand NPY were determined by ELISA.A new mathematics method of the trend of percentage rate of change(PRC)was used to assess the correlation between pharmacokinetics(PK)and pharmacodynamics(PD).Results:FA-Pr-Al in combination reduced neurological deficits,decreased infarct volume and inhibited the expression levels of IL-1βand NPY(all P0.05)compared with the model group.FA,Pr and Al all displayed two compartment open models in rats.Clockwise hysteresis loops were obtained by time-concentration-effect curves.IL-1βand NPY level changes in the plasma followed an opposite trend to the plasma concentration tendency after C_(max)was reached.Astragaloside's PRC value was significantly higher than those of FA and puerarin between 120 to 180 min.Conclusions:The pharmacokinetics of FA-PrAl in combination were closely related its pharmacodynamics in treating ischemia/reperfusion injury,and the components of FA-Pr-Al may have a synergistic pharmacological effect.Astragaloside may play a more pronounced role in regulating IL-1βand NPY levels compared with puerarin or FA.

【参考文献】
中国期刊全文数据库 前1条
1 王玉;朱慧渊;郭莹;韩进;万海同;;葛根素对局灶性脑缺血再灌注模型大鼠脑组织水肿及神经细胞Na~+-K~+-ATPase、Ca~(2+)-ATPase活性的影响[J];中国中医急症;2007年01期
【共引文献】
中国期刊全文数据库 前10条
1 黄绵庆;杨照新;姚茂忠;田树红;符健;;葛根素对中波紫外线损伤HaCaT细胞的抗氧化作用[J];重庆医学;2012年19期
2 潘登;张三强;师桂萍;谭军;;葛根素预处理对大鼠脑缺血再灌注损伤后脑组织含水量的影响[J];临床心身疾病杂志;2008年02期
3 陈英;吴友根;张军锋;杨东梅;林尤奋;;广藿香生物活性和遗传多样性研究进展[J];热带生物学报;2013年03期
4 于继强;高尔;;葛根素对心脑血管系统药理作用研究进展[J];现代中西医结合杂志;2008年24期
5 于文红;初桂兰;;葛根素对缺氧缺血性脑损伤保护作用的研究进展[J];医学综述;2009年20期
6 关丽华;秦博文;商亚珍;;黄芩茎叶中黄酮提取物对过氧化氢诱导的大鼠皮层神经元损伤的保护作用[J];中国新药杂志;2013年07期
7 刘煜洪;罗丹丹;温锦青;陈海明;蒋丽芸;吴志坚;苏子仁;黄玉梅;高明;;GC法测定复方野菊花抗感软胶囊中广藿香醇的含量[J];中药新药与临床药理;2014年04期
8 胡锐宁;李菲;朱承科;胡夏逢;夏君;林敏浩;周诚;;补阳还五汤复方颗粒对缺血性脑卒中模型大鼠血浆中强啡肽和神经肽Y的影响[J];中国实验方剂学杂志;2014年19期
9 黄雄峰;汪建民;;葛根素的神经保护作用机制研究进展[J];中国实验方剂学杂志;2015年04期
10 吴雪松;许浚;张铁军;陈常青;;野菊的化学成分及质量评价研究进展[J];中草药;2015年03期
中国博士学位论文全文数据库 前3条
1 于文红;新生大鼠缺氧缺血性脑损伤后NPTX1表达及葛根素脑保护作用[D];天津医科大学;2010年
2 李雪;芒果苷对脑缺血再灌注损伤的保护作用及其机制研究[D];南方医科大学;2014年
3 周伟;基于“银翘”药对的中药制剂生物有效性综合评价体系的构建与应用[D];南京中医药大学;2014年
【二级参考文献】
中国期刊全文数据库 前2条
1 李建生,赵晶,高爱社,赵君玫,李建国,王霄华;补肾活血和泻下及开窍活血方药对脑缺血再灌注肺损伤老龄大鼠ATP酶和自由基代谢的影响[J];中国中医急症;2001年06期
2 袁莉,冼明健,江先娣,杨职,黎朝茂,方玲,蓝崧;葛根素促进急性缺血性脑卒中患者神经功能恢复及对血液流变学的影响[J];中国中医急症;2005年07期
【相似文献】
中国期刊全文数据库 前10条
1 ;Studies on molecular interactions between puerarin and PC liposomes[J];Chinese Science Bulletin;2007年19期
2 赵瑛;周游;殷惠军;张颖;;Effect of puerarin on the P13K pathway for glucose transportation and insulin signal transduction in adipocytes[J];Journal of Harbin Institute of Technology;2009年01期
3 ;Study on the Extraction Technology of Puerarin from RADIX PUERARIAE by Ultrasonic and Microwave Assisted Extraction[J];Medicinal Plant;2011年05期
4 申佳;孟甄;苏慧;邢东明;丁怡;杜力军;;Different Kinetics of Puerarin in Plasma of Normal and Depressed Rats After Oral Administration of Chinese Medicine TZ18[J];Tsinghua Science and Technology;2007年04期
5 Huang Zhu;Xiaojing Cai;Xianqun Fan;;Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields[J];Journal of Traditional Chinese Medicine;2013年05期
6 WANG Chang;MENG Mei-Xia;TANG Xu-Lei;CHEN Ke-Ming;ZHANG Li;LIU Wei-Ning;ZHAO Ying-Yong;;The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro[J];Chinese Journal of Natural Medicines;2014年06期
7 吴海琴;郭荷娜;王虎清;常明则;张桂莲;赵英贤;;Protective Effects and Mechanism of Puerarin on Learning-Memory Disorder after Global Cerebral Ischemia-Reperfusion Injury in Rats[J];Chinese Journal of Integrative Medicine;2009年01期
8 张明宇;强辉;杨华清;党晓谦;王坤正;;In Vitro and In Vivo Effects of Puerarin on Promotion of Osteoblast Bone Formation[J];Chinese Journal of Integrative Medicine;2012年04期
9 WEI Shu-Yong;CHEN Yi;XU Xiao-Yu;;Progress on the pharmacological research of puerarin: a review[J];Chinese Journal of Natural Medicines;2014年06期
10 Jiarui Wu;Xiaomeng Zhang;Bing Zhang;;Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and Meta-analysis of randomized controlled trials[J];Journal of Traditional Chinese Medicine;2014年04期
中国重要会议论文全文数据库 前8条
1 ;Protective Effect of Methylamine Irisolidone,a Novel Compound,on Acute Myocardial Ischemia in Rats[A];2008心血管药理学术研讨会论文汇编[C];2008年
2 ;Influence of puerarin on the expression of tissue factor induced by angiotensinⅡ and its mechanism in vascular endothelial cells[A];传承与发展,创湖南省生理科学事业的新高——湖南省生理科学会2011年度学术年会论文摘要汇编[C];2011年
3 ;Effects of puerarin on burn injury pain mediated by P2X_3 receptor[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
4 ;Synthesis of Dialkyl puerarin-7-yl Phosphates and Study on the Interaction with Cytochrome C by ESI-MS[A];第五届全国化学生物学学术会议论文摘要集[C];2007年
5 ;Study of puerarin in the signalling of myocardial ischemia mediated by P2X_7 receptor of superior cervical ganglion[A];中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集[C];2011年
6 ;Opening of mitochondrial calcium activated potassium channel participates in the cardioprotective effect of puerarin[A];浙江省生理科学会2006年学术年会论文汇编[C];2006年
7 ;Hypolipidemic Effect of Puerarin and Underlying Mechanism Investigation[A];第十三次全国临床药理学学术大会论文汇编[C];2012年
8 Chang-Shui XU;Bo FAN;Shang-Dong LIANG;;Role of puerarin in the signalling of neuropathic pain mediated by P2X4 receptor of spinal dorsal horn microglia[A];中国神经科学学会第十届全国学术会议论文摘要集[C];2013年
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026