| | | | | 多囊性卵巢综合征患者血清C反应蛋白水平与临床因素相关性的分析 | | | 胡卫红;乔杰;王丽娜;张小为;李美芝 | | | 目的探讨多囊性卵巢综合征(PCOS)患者血清中C反应蛋白(CRP)的浓度与临床因素的相关性。方法对90例PCOS患者及20例正常对照组应用免疫比浊法检测血清中CRP水平,同时应用生化法检测血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)及高密度脂蛋白-胆固醇(HDL-C);对PCOS患者进行葡萄糖耐量(OGTT)及胰岛素释放实验。根据体重指数(BMI),PCOS患者分为肥胖组48例(BMI≥25kg/m2),非肥胖组42例(BMI<25kg/m2)。结果①肥胖及非肥胖PCOS患者logCRP均明显高于正常对照组(P<0.05),肥胖PCOS患者logCRP明显高于非肥胖PCOS患者(P<0.05);②Pearson相关分析显示,logCRP与BMI、HOMA-IR呈正相关(P<0.05);与HDL-C和胰岛素敏感指数(ISI)呈负相关(P<0.05)。排除BMI影响后的偏相关分析显示,logCRP与HOMA-IR呈正相关(P<0.05),与ISI呈负相关(P<0.05)。结论PCOS患者机体内可能存在着一种慢性炎症状态;PCOS患者血清CRP水平的升高可能是预测2型糖尿病的一个危险因子。
【作者单位】：北京大学第三医院妇产科;北京大学第三医院妇产科;北京大学第三医院妇产科;北京大学第三医院妇产科;北京大学第三医院妇产科 100083;在职博士;现在北京武警总医院妇产科;100083;100083;100083;100083
【关键词】：多囊卵巢综合征(PCOS);C-反应蛋白(CRP);慢性炎症
【基金】：国家自然科学基金(30570872)资助
【分类号】：R711.75
【DOI】：CNKI:ISSN:1672-1861.0.2007-01-012
【正文快照】：
多囊性卵巢综合征(polycystic ovarian syn-drome,PCOS)是妇科常见的内分泌紊乱性疾病,临床上主要表现为月经稀发、闭经、肥胖、多毛、不孕,胰岛素抵抗和高胰岛素血症是PCOS的一个病理生理基础。流行病学调查证实PCOS患者发生2型糖尿病、高血压、冠心病等疾病的危险性明显升高 | | | | | |  推荐 下载CAJ全文  下载PDF全文 | | | CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式 | | | | Serum C-reactive protein and its relationship with clinic factors in patients with polycystic ovary syndrome | | | HU Weihong;QIAO Jie;WANG Lina;et al. (Department of Obstetrics and Gynecology;Peking University Third Hospital;Beijing 100083;China) | | | Objective To measure serum C-reactive protein (CRP) levels and analyze its associations with clinical factors in patients with polycystic ovary syndrome (PCOS).Methods Ninety PCOS women and 20 ovulating healthy women with body mass index (BMI) <25 kg/m2 as controls were recruited. PCOS women were divided to two groups: 48 BMI≥25 kg/m2 patients as obese group; 42 BMI<25 kg/m2 as non-obese group. Serum CRP was assayed by immunoturbidimetry. And triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C)and low density lipoprotein cholesterol (LDL-C) were measured. Oral glucose tolerance test (OGTT) and insulin sensitivity were also assessed in PCOS patients.Results ① Obese and non-obese PCOS group presented markedly higher logCRP than controls group (both P<0.05), and the logCRP is higher in the obese PCOS group than non-obese PCOS group (P<0.05). ② Univariate analysis revealed that logCRP was significantly and positively correlation with BMI and HOMA-IR(P<0.05); LogCRP was significantly and negatively correlation with HDL-C and ISI(P<0.05)in patients with PCOS. Partial correlation showed that logCRP was correlation with HOMA-IR(P<0.05), and logCRP was significantly and negatively correlation with ISI(P<0.05)in patients with PCOS. Conclusions Chronic inflammation maybe exists in patients with PCOS. CRP may be a predictor of future type 2 diabetes mellitus in PCOS patients.
【Keyword】：polycystic ovary syndrome;C-reactive protein;chronic inflammation |
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