| | | | | 骨骼肌纤维类型在不同的条件下的转化研究 | | | 李江华;刘承宜 | | | 随着研究条件与相关技术的发展,近年来科研人员对骨骼肌纤维类型进行了大量的细胞与分子生物学水平的研究。研究发现,除发育因素外,神经支配,运动训练,负荷或去负荷,激素以及衰老等各种因素均对骨骼肌纤维的特异蛋白质表达产生影响,乃至改变肌纤维的种类和肌肉的肌纤维组成。对于成体已发育成熟的骨骼肌来说,在此情况下无论是何种因素引起的肌纤维转化,似乎都与神经支配和神经-肌肉或神经-内分泌活动的变化有关。目前对骨骼肌纤维转化的机理存在多种解释,其中以Chin等根据对成肌细胞培养的研究结果率先提出"骨骼肌特异纤维类型基因表达受钙调神经磷酸酶(calcineurin)依赖性转录信号途径(signaling pathway)控制"这一学说为代表。但是这些理论都不成熟,对骨骼肌纤维转化的机制还需要进一步研究。
【作者单位】：华南师范大学体育科学学院激光运动医学实验室 广东广州510006
【关键词】：肌纤维类型;骨骼肌;转化
【分类号】：G804.2
【DOI】：CNKI:SUN:BTSF.0.2008-02-015
【正文快照】：
骨骼肌在机体生命活动中所扮演的角色决定了它永远是生命科学,尤其是运动生理学研究的重要领域。不同类型肌纤维在收缩力量、收缩速度和抗疲劳能力方面有明显的差异,并且肌纤维类型构成的变化与衰老导致的肌力丢失密切相关,因此骨骼肌纤维类型的转化研究一直是国际运动生理学界 | | |  推荐 CAJ下载  PDF下载 | | | CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式 | | | | A Study on the Transition of Skeletal Muscle Fiber Types under Varied Conditions | | | LI Jiang-hua;LIU Cheng-yi Laboratory of Laser Sports Medicine;School of Sports Science;South China Normal University;Guangzhou 510006;China. | | | In recent years,with the development of the research condition and relative technology,the researchers have done a great deal of study in the field of skeletal muscle fiber types at the cellular and molecular level of biology.Research shows that their phenotypic profiles are affected by innervations/neuromuscular activity,exercise training,mechanical loading/unloading,hormones and aging besides genetic factors.These factors may change skeletal muscle types and the composition of muscle fibers.For skeletal muscles that are genetically mature,they are closely related with the changes of innervations,neuromuscular and internal secretion activities under the same constitution regardless of the transition of muscle fiber caused by any factors.At present,there are several theories put forward to explain the mechanism of transition of muscle fibers.The typical one is proposed initially by Chin et al according to the research results in the breeding of matured muscle cells.They argue that the gene expression of a given skeletal muscle fiber type is regulated by the transcription signaling pathway depending on calcineurin.However,none of these theories are dominant.It seems they are all premature.The mechanism of the transition of skeletal muscle fiber needs further researches.
【Keyword】：Muscle fiber types;Skeletal muscle;Transition |
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