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《Current Zoology》 2010年06期
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Roles of the main olfactory and vomeronasal systems in the detection of androstenone in inbred strains of mice

Vera V. VOZNESSENSKAYA  Maria A. KLYUCHNIKOVA  Charles J. WYSOCKI  
【摘要】:正 We investigated the role of the main olfactory and accessory olfactory systems (MOS and AOS respectively) in thedetection of androstenone. We used the following experimental approaches: behavioral, surgical removal of the vomeronasal organ(VNX) followed by histochemical verification and Fos immunohistochemistry. Using a Y-maze paradigm we estimated sensitivityof NZB/B1NJ and CBA/J mice to androstenone. CBA mice were 2,000-fold more sensitive to androstenone than NZB mice.VNX caused a 4- to 16-fold decrease in sensitivity to androstenone in highly-sensitive CBA mice, but did not affect thresholds inNZB mice. Results indicate the involvement of the MOS and AOS in the detection of androstenone. We observed a specific patternof Fos-positive cells in the main olfactory bulb of CBA mice but not in NZB mice subsequent to exposure of mice to androstenone;the compound activated cells in the accessory olfactory bulb in both strains of mice, indicating the involvement of thevomeronasal organ. Patterns of Fos-positive cells in the vomeronasal organ were recorded subsequent to exposure to androstenone.Fos-positive receptor cells in the vomeronasal organ of CBA and NZB mice were different, in CBA mice Fos-positive cellswere noted in both the basal and apical zones, however, in NZB mice activation was observed only in the apical zone

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