收藏本站
《World Journal of Gastroenterology》 2014年34期
收藏 | 投稿 | 手机打开
二维码
手机客户端打开本文

Hepatitis C virus infection in the human immunodeficiency virus infected patient

Louise Nygaard Clausen  Lene Fogt Lundbo  Thomas Benfield  
【摘要】:Human immunodeficiency virus(HIV)and hepatitis C virus(HCV)share the same transmission routes;therefore,coinfection is frequent.An estimated 5-10 million individuals alone in the western world are infected with both viruses.The majority of people acquire HCV by injection drug use and,to a lesser extent,through blood transfusion and blood products.Recently,there has been an increase in HCV infections among men who have sex with men.In the context of effective antiretroviral treatment,liver-related deaths are now more common than Acquired Immune Deficiency Syndromerelated deaths among HIV-HCV coinfected individuals.Morbidity and mortality rates from chronic HCV infection will increase because the infection incidence peaked in the mid-1980s and because liver disease progresses slowly and is clinically silent to cirrhosis and end-stage-liver disease over a 15-20 year time period for 15%-20%of chronically infected individuals.HCV treatment has rapidly changed with the development of new direct-acting antiviral agents;therefore,cure rates have greatly improved because the new treatment regimens target different parts of the HCV life cycle.In this review,we focus on the epidemiology,diagnosis and the natural course of HCV as well as current and future strategies for HCV therapy in the context of HIV-HCV coinfection in the western world.
【作者单位】Department
【分类号】:R512.63

【相似文献】
中国重要会议论文全文数据库 前7条
1 ;Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong province,China:a cross sectional study[A];新发和再发传染病防治热点研讨会论文集[C];2011年
2 Rodney E.Willoughby;;Treatment of Human Rabies[A];2010全国狂犬病防控高层论坛论文集[C];2010年
3 周庆涛;贺蓓;姚贝;刘振英;张捷;;Dissemination of carbapenem-resistant Acinetobacter baumannii in a Chinese university hospital and analysis of infected patients' prognosis[A];第十届全国化疗药理暨抗感染药理高峰论坛资料汇编[C];2010年
4 Seto Wing Hong;;Preventing SARS Back to the Basics in Infection Control[A];中华医院管理学会第十届全国医院感染管理学术年会论文汇编[C];2003年
5 ;Dual Th1/Treg and Th17/Treg imbalances ofα4+β7+RO+CD4+ T cells in HIV-1 infection after prolonged antiretroviral therapy[A];中华医学会第五次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议论文汇编[C];2011年
6 ;Clinical Study of Influenza A(H1N1) Virus Infection in Pandemics Peak of 2009 Winter[A];中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议论文汇编[C];2011年
7 ;Inhibition of pre-B cell colony-enhancing factor attenuates inflammation and apoptosis induced by pandemic H1N1 2009 in lung endothelium[A];中华医学会呼吸病学年会——2011(第十二次全国呼吸病学学术会议)论文汇编[C];2011年
中国博士学位论文全文数据库 前1条
1 阿玛杜(AMADOU Ibrahim Halilou);慢性HBV感染不同时期调节性T细胞的比例变化[D];华中科技大学;2013年
中国硕士学位论文全文数据库 前1条
1 Seno Lamsir(蓝海聪);[D];重庆医科大学;2013年
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026