| | | | | Accuracy of Helicobacter pylori serology in two peptic ulcer populations and in healthy controls | | | Rolv-Ole Lindsetmo;Roar Johnsen;Tor Jac Eide;Tore Gutteberg;Hanne Haukland Husum;Arthur Revhaug | | | AIM: To estimate the test characteristics of Heli- cobacter pylori (Hpylori) serology and of C14-urea breath test (C14-UBT) in two different peptic ulcer populations and in community controls. Second, the aim was to explore the association between the level of H pylori IgG antibodies and severity of inflammation as to active peptic ulceration in the same populations. METHODS: Vagotomized (n= 83), medically treated peptic ulcer patients (n=73) and one reference group of community controls (n=88) were gastroscoped. H pylori status was determined by histology, bacterial growth, C14-UBT and serology. Based on the updated Sydney System, cumulative scores from biopsies from the prepyloruos, incisura angularis, corpus and fundus were calculated. RESULTS: The prevalence of H pylori infection varied from 70% to 79%. The C14-UBT had high accuracycompared to the serology test. The sensitivity of the serology test was good, but the specificity was low (41%-71%). The association between H pylori IgG antibodies and scores of gastric mucosal inflammation and current or previous peptic ulcer were weak. CONCLUSION: The accuracy of C14-UBT to diagnose H pylori infection was good, and the clinical utility of a negative H pylori serology test was substantial, while the gain in clinical information of a positive test was meagre. Positive H pylori titres could not distinguish between subjects with or those without active peptic ulceration.
【作者单位】：Department of Gastrointestinal Surgery;University Hospital of North Norway and Institute of Clinical Medicine;Troms University;Institute of Public Health and General Practice;Norwegian University of Science and Technology;Department of Pathology;National Hospital;Department of Microbiology;University Hospital of North Norway
【分类号】：R573.1
【DOI】：CNKI:SUN:ZXXY.0.2008-32-011
【正文快照】：
INTRODUCTION Serology and C14-urea breath test (C14-UBT) are the most commonly used non-invasive tests of Helicobacter pylori (H pylori) infection[1-3]. Knowledge about the diag- nostic validity of particular serological tests is manda- tory for inferring… | | |
| | |  推荐 CAJ下载  PDF下载 | | | CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式 | | | | Accuracy of Helicobacter pylori serology in two peptic ulcer populations and in healthy controls | | | Rolv-Ole Lindsetmo;Department of Gastrointestinal Surgery;University Hospital of North Norway and Institute of Clinical Medicine;TromsUniversity;Troms N-9036;Norway Roar Johnsen;Institute of Public Health and General Practice;Norwegian University of Science and Technology;Trondheim N-7006;Norway Tor Jac Eide;Department of Pathology;National Hospital;Oslo N-0027;Norway Tore Gutteberg;Hanne Haukland Husum;Department of Microbiology;University Hospital of North Norway;Troms N-9036;Norway Arthur Revhaug;Department of Gastrointestinal Surgery;University Hospital of North Norway and Institute of Clinical Medicine;Troms University;TromsN-9036;Norway | | | AIM: To estimate the test characteristics of Heli- cobacter pylori (Hpylori) serology and of C14-urea breath test (C14-UBT) in two different peptic ulcer populations and in community controls. Second, the aim was to explore the association between the level of H pylori IgG antibodies and severity of inflammation as to active peptic ulceration in the same populations. METHODS: Vagotomized (n= 83), medically treated peptic ulcer patients (n=73) and one reference group of community controls (n=88) were gastroscoped. H pylori status was determined by histology, bacterial growth, C14-UBT and serology. Based on the updated Sydney System, cumulative scores from biopsies from the prepyloruos, incisura angularis, corpus and fundus were calculated. RESULTS: The prevalence of H pylori infection varied from 70% to 79%. The C14-UBT had high accuracycompared to the serology test. The sensitivity of the serology test was good, but the specificity was low (41%-71%). The association between H pylori IgG antibodies and scores of gastric mucosal inflammation and current or previous peptic ulcer were weak. CONCLUSION: The accuracy of C14-UBT to diagnose H pylori infection was good, and the clinical utility of a negative H pylori serology test was substantial, while the gain in clinical information of a positive test was meagre. Positive H pylori titres could not distinguish between subjects with or those without active peptic ulceration.
【Keyword】：C14-urea breath test;Gastric inflammation;Helicobacter pylori serology;Peptic ulcers;Test characteristics |
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