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《World Journal of Gastroenterology》 2001年02期
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Inhibitory effect of voglibose and gymnemic acid on maltose absorption in vivo

Toshiaki Imoto  Yasutake Hiji  
【摘要】:正 AIM To determine whether diabetic care can be improved by combination of voglibose and gymnemic acid ( GA ), we compared thecombinative and individual effects of voglibose and GA on maltose absorption in small intestine.METHODS The small intestine 30 cm long from 2 cm caudal ward Treitz's ligament of Wistar rat was used as an in situ loop, which was randomly perfused in recircular mode with maltose (10 mmol/ L) with or without different dosages of voglibose and/or GA for an hour. To compare the time course, perfusion of 10 mmol/L maltose was repeated four times. Each time continued for 1 hour and separated by 30 minutes rinse. In the first time, lower dosages of GA (0.5g/L) and/or voglibose (2 μmolL) were contained except control.RESULTS Absorptive rate of maltose was thelowest in combinative group (P0.05, ANOVA), for example, the inhibition rate was about 37% during the first hour when 0.5g/L GA and2 μmol/L voglibose with 10 mmol/L maltose were perfused in the loop. The onset time was shortened to 30 minutes and the effective duration was prolonged to 4 hours with thecombination; therefore the total amount of maltose absorption during the effective duration was inhibited more significantly than that in theindividual administration (P0.05, U test of Mann-Whitney). The effect of GA on absorptive barriers of the intestine played an important role in the combinative effects.CONCLUSION There are augmented effects of voglibose and GA. The management of diabetes mellitus can be improved by employing the combination.
【作者单位】Departments
【基金】:Supported by Japanese Government (Ministry of Education,Science and Culture of Japan, MONBUSHO) scholarship No.933241(1994-1999)
【分类号】:R587.1
【正文快照】:
INTRODUCTION1 t has been well known that there 15 an assoeiationbetween hyPerglyeemia and diabetie eomPlieation.Patients who develoP non一inst一lin一dePendent diabetesmellitus(NIDDM)even at:、ge 65 ye盯5 may livelong enough to devcloP miero一vaseular and

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