| | | | | p38-MAPK与脓毒症诱导的心肌功能障碍 | | | 王大伟;周荣斌 | | | 脓毒性心肌病是脓毒症和脓毒性休克的严重并发症,多种分子机制参与了脓毒症诱导的心肌功能障碍(sepsis-induced myocardial dysfunction,SIMD)。丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号转导途径是体内重要的信号转导通路。MAPK家族中的p38-MAPK参与了SIMD分子信号及凋亡机制。探讨p38-MAPK的分子结构,p38-MAPK信号转导通路的特点,以及p38-MAPK在SIMD发病机制中的作用。
【作者单位】：解放军北京军区总医院急诊科 100700北京
【关键词】：丝裂原活化蛋白激酶;脓毒症;信号转导;凋亡;脓毒症诱导的心肌功能障碍
【基金】：全国血必净脓毒症研究基金项目(No.Z20040033)
【分类号】：R459.7
【DOI】：CNKI:SUN:ZJJY.0.2008-07-027
【正文快照】：
脓毒症是一种由严重的全身感染引发的复杂免疫,代谢及心血管病症。脓毒性休克的死亡率持续上升,高死亡率与患者年龄和心肌病理学改变密切相关。心肌功能障碍是脓毒症的主要临床表现之一,1984年Parker[1]首次报道了脓毒性休克患者心肌抑制的相关证据。脓毒症以高血流动力学状态, | | | | | |  推荐 下载CAJ全文  下载PDF全文 | | | CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式 | | | | p38-MAPK and sepsis-induced myocardial dysfunction | | | WANG Da-wei;ZHOU Rong-bin.Emergency Department;General Hospital of Beijing Military Region;PLA;Beijing 100700;China | | | Septic cardiomyopathy is a severe complication of sepsis and septic shock.Many molecular mechanisms may be involved in sepsis-induced myocardial dysfunction(SIMD).Mitogen-activated protein kinase(MAPK) is one of the important signal transduction systems in organisms.The p38-MAPK,a number of MAPK family,is involved in molecular signal and apoptosis mechanisms of SIMD patients.We review recent advances in the understanding of molecular structure of p38-MAPK,characters of p38-MAPK signal transduction way and the role of p38-MAPK in the pathogenesis of SIMD.
【Keyword】：p38-MAPK;Sepsis;Apoptosis;Sepsis-induced myocardial dysfunction(SIMD) |
| | | | | | 1 | Parke M M, Shelhamer J H, Bacharch S l, et al; Profound but reversible myocardial depression in patients with septic shock [M];Ann Inter Med; 1984年 | | 2 | Han J, Lee JD, Bibbs L, et al; A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells [M];Science; 1994年 | | 3 | Keesler G A,Bray J,Hunt J,et al; Purification and activa-tion of recombinant p38isoformsα,β,γ,andδ [M];Protein Exp Purif; 1998年 | | 4 | Sharma AC,Motew SJ,Farias S,et al; Sepsis alters myocard ial andplasma concentrations of endothelin and n itric oxide in rats [M];JMolCell Card iol; 1997年 | | 5 | Xia Z, Dickens M, Raingeaud J, et al; Opposing effects of ERK and JNKp38 MAP kinases on apoptosis [M];Science; 1995年 | | 6 | Yanagisawa M, Kurihara H, Kimura S, et al; A novel potent vasoconstrictor peptide produced by vascular endothelial cells [M];Nature; 1988年 | | 7 | Kyriakis JM, Avruch J; Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation [M];Physiol Rev; 2001年 | | 8 | Cook S,Sugden P,Clerk A; Activation of c-jun N-terminal kinases and p-38 mitogen activated protein kinases in human heart failure secondary to ischemic heart disease [M];J Mol Cell Cardial; 1999年 | | 9 | Clerk A, Michael A, Sugden PH; Stimulation of the p38 mitogen- activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists,endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy? [M];J Cell Biol; 1998年 | | 10 | Livingstone C, Patel G, Jones N; ATF-2 contains a phosphorylation-dependent transcriptional activation domain [M];EMBO J; 1995年 |
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| | | | | | 1 | 齐咏,马利军,吴继珍; 丝裂原活化蛋白激酶抑制剂对急性肺损伤影响 [J];医药论坛杂志; 2006年21期; 30-32 | | 2 | 向启利,李建福,付小兵; 丝裂原活化蛋白激酶通路介导创面渗出液对大鼠表皮干细胞内游离钙浓度的影响 [J];中国病理生理杂志; 2007年06期; 149-152 | | 3 | 李国辉,徐庆连; 大鼠烫伤后肾脏组织p38丝裂原活化蛋白激酶的活化及肿瘤坏死因子α含量的变化 [J];中华烧伤杂志; 2006年02期; 58-59 | | 4 | 黄政坤,包建东,戴军,苏海丰,张云仙; p38MAPK抑制剂对急性肺损伤大鼠肺组织核因子-κB表达的影响 [J];临床麻醉学杂志; 2007年04期; 59-60 | | 5 | 郑峻松,彭代智,黄文华,罗高兴,黄辉,刘敬,周新; 细胞信号转导调控剂对严重烫伤小鼠T淋巴细胞分泌功能的影响及机制 [J];中华烧伤杂志; 2006年06期; 23-26 | | 6 | 贾一韬,韦多,夏照帆,田建广; p38丝裂原活化蛋白激酶在应激性溃疡发病中的作用 [J];中华外科杂志; 2005年19期; 56-59 |
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