| | | | | 光纤药物在位溶出度/释放度监测仪实时监测复方盐酸阿米洛利片体外溶出度 | | | 吴军;李新霞;陈坚 | | | 目的:采用光纤化学传感技术实时、在位监测固体制剂体外溶出度的测定并与2000年版中国药典方法比较。方法:应用光纤原位药物溶出度/释放度试验仪,将分支光纤一端连接光源,公共端部探头浸入溶出液;另一端连接检测器,计算机记录并处理数据。结果:本法监测药物溶出的全过程,显示药物实时溶出曲线图,直接提取相关参数,与药典方法比较,无统计学差异(P>0.05)。结论:光纤化学溶出度过程监测法能够有效地测定固体药物的体外溶出度,并能真实地反映药物溶出的全过程。
【作者单位】：新疆医科大学公共卫生学院;新疆医科大学药学院;新疆医科大学药学院 乌鲁木齐 830054;乌鲁木齐 830054;乌鲁木齐830054
【关键词】：光纤溶出度/释放度过程监测法;药典溶出度测定方法;复方盐酸阿米洛利片
【基金】：新疆维吾尔自治区高技术发展计划资助项目(200311110)
【分类号】：R927
【DOI】：CNKI:SUN:YWFX.0.2007-02-029
【正文快照】：
光纤传感器技术是上世纪70年代随着光导纤维实用化和光通信技术的发展而形成的。光纤化学传感器(fiber optie ehemieal sensor,FOCS)是在光导纤维的端部安装一个对分析物有响应的试剂相(探头),探头将光学性质(光强、荧光、光谱、偏振态或折射等)的变化通过光纤传送至检测器监测 | | |  推荐 CAJ下载  PDF下载 | | | CAJViewer7.0阅读器支持所有CNKI文件格式，AdobeReader仅支持PDF格式 | | | | The real-time optic fiber chemical sensor dissolution test detection method and conditions for compound amiloride hydrochloride tablets | | | WU Jun~1 LI Xin-xia~2 CHEN Jian~2(1.College of Publie Health;Xinjiang Medical University;Urumqi 830054;China2.College of Pharmacy;Xinjiang Medical University;Urumqi 830054;China) | | | Objective:To study a method which can monitor the dissolution rate of drug on-line-fiber optic chemical sensor dissolution test(FOCSDT).And compare the difference of this method with CHP(2000).Method: By mean of FOCSDT,bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the dissolution vessel.The dissolution procession could be monitored through computer.Result:This pro- cession analysis could test the whole process of drug and get dissolution graph.The parameters obtained by FOCSDT had no significant difference compared with the method in ChP 2000(P>0.05).Conclution:This procession anal- ysis can reflect the real dissolution of drug and obtain the total information.
【Keyword】：fiber;optic chemical sensor dissolution test(FOCSDT);ChP(2000)dissolution test;compound amiloride hydrochloride tablets |
|
|