【摘要】：[Objectives] The purpose of this paper was to study the effects of Suoquan Yishen formula on mice with diabetic nephropathy(DN). [Methods] The mice were randomly divided into normal group, model group, irbesartan group, and high and low-dose Suoquan Yishen formula groups. The blood glucose level, BUN, Scr excretion and GSH activity and CAT activity were detected. [Results] The blood glucose levels of mice in the irbesartan group and high and low-dose Suoquan Yishen formula groups decreased. The BUN, PRO and Scr levels were higher and the GSH and CAT activity was lower in the model group compared with the normal group. After administration of Suoquan Yishen formula, the BUN, PRO and Scr levels of the DN mice decreased significantly, and the GSH and CAT activity increased significantly. [Conclusions] Suoquan Yishen formula can reduce blood glucose level, reduce PRO, BUN and Scr levels, and increase CAT and GSH activity in DN mice, thus protecting the ND mice.