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《Science China(Life Sciences)》 2017年05期
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CRISPR/Cas9-mediated base-editing system efficiently generates gain-of-function mutations in Arabidopsis

Yiyu Chen  Zhiping Wang  Hanwen Ni  Yong Xu  Qijun Chen  Linjian Jiang  
【摘要】:正Dear Editor,The CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9)system is revolutionizing genome editing due to its high efficiency,low cost,design simplicity and versatility.However,introduction of a point mutation at a desired position remains a great challenge in plant genome engineering.Currently,point mutation in plants was achieved by incorporating a

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