【摘要】：正 A possible link is suggested between hepatic diseases and rheumatic disease. Polyarthralgia and polyarthritismay be seen during the prodromal period of acute viral hepatitis, especially in hepatitis B virus (HBV). Thesymptoms of arthritis, mild, localized or generalized, mostly involve the small joints of hands. Jointsymptoms frequently precede the onset of jaundice, no residual joint deformities. Circulating immunecomplexes are believed to play a causative role in the development of vasculitis and arthritis.Hemochromatosis is an antosomal recessive disorder of iron. About 43%-81% of patients withhemochromatosis have arthritis. The common extrahepatic manifestations of autoimmune hepatitis arearthralgia and skin rash. The reported prevalence of symptomatic inflammatory arthropathy in patients withprimary biliary cirrhosis ranges from 4% to 50%. Skeletal involvement with Wilson's disease is common.Such patients may complain of pain and stiffness, mainly in the knee, wrist, or other large joints.Shwachman's syndrome is a disorder of pancreatic exocrine. Symmetric bone lesions have been reported in10% to 15% of patients. They are involved predominantly at the femoral neck. Rheumatic symptoms areseen in one third of adult patients with cystic fibrosis and arthritis in 2.5% to 12% of patients. The arthritiscaused by pancreatic panniculitis is usually symmetrical and involves the small joints of the hand, wrist, andfeet, but may involve such larger joints as the elbow, ankle, and knee.