小儿药物性血尿32例临床分析--《国际医药卫生导报》2004年16期

《国际医药卫生导报》2004年16期

小儿药物性血尿32例临床分析

　　目的探讨药物性血尿的常见原因及相关因素。方法对32例药物性血尿患儿的临床资料进行回顾性分析总结。结果在引起药物性血尿中,解热镇痛药15例(46.9％),先锋霉素7例(21.9％),氨基糖甙类抗生素5例(15.6％),另外磺胺药2例,氟哌酸1例,中药抗病毒冲剂2例也可引起血尿。药物性血尿的发生既可能与药物剂量有关(剂量依赖性),也可能与剂量无关(非剂量依赖性)。结论引起药物性血尿的常见原因与不合理用药有关,临床医生应注意药物性血尿发生的危险因素。
【作者单位】：广州医学院第二附属医院儿科;广州医学院第二附属医院儿科;广州医学院第二附属医院儿科广东广州 510260;广东广州 510260;广东广州 510260
【关键词】：药物性血尿;临床分析;儿童
【分类号】：R725.9
【DOI】：cnki:ISSN:1007-1245.0.2004-16-007
【正文快照】：
　　血尿为泌尿系统常见症状之一,在引起血尿的原因之中,药物引起的肾脏损害是常见原因之一,有报道不同药物引起的肾脏损害当中,镜下血尿或肉眼血尿见于35%~95%的病例[‘],为了进一步探讨小儿药物性血尿发生的原因和机制,合理应用药物,本文对32例药物性血尿患者的临床资料进行分析,现报道如下: 1资料与方法 1.1一般资料从1995年l月至2003年12月间我院收治的32例药物性血尿患者,年龄<3岁9例,~5岁11例,一8岁7例,一14岁5例,男19例,女13例。发生药物性血尿存在的基础性疾病:急性_L呼吸道感染14例,支气管炎8例,肺炎5例,肠炎5例,既往无肾脏病史,除外…

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inical Analysis of 32 Children with Medicinal Hematuria</td></tr><tr><td width='16'> </td><td width='595' align='center' valign='middle'><a style='cursor:hand;color:blue;' onClick="TPI_openwindow('http://epub.cnki.net/grid2008/knowledgenet.aspx?sdb=CJFD&sfield=%e8%8b%b1%e6%96%87%e4%bd%9c%e8%80%85&skey=%3cauthor%3e', 'knet','status=yes,scrollbars=yes,width=375,height=250')"><author> Zequan HUANG Cuiwen LI MinDepartment of Paediatrics</a>;<a style='cursor:hand;color:blue;' onClick="TPI_openwindow('http://epub.cnki.net/grid2008/knowledgenet.aspx?sdb=CJFD&sfield=%e8%8b%b1%e6%96%87%e4%bd%9c%e8%80%85&skey=Second', 'knet','status=yes,scrollbars=yes,width=375,height=250')">Second Affiliated Hospital</a>;<a style='cursor:hand;color:blue;' onClick="TPI_openwindow('http://epub.cnki.net/grid2008/knowledgenet.aspx?sdb=CJFD&sfield=%e8%8b%b1%e6%96%87%e4%bd%9c%e8%80%85&skey=Guangzhou', 'knet','status=yes,scrollbars=yes,width=375,height=250')">Guangzhou Medical College</a>;<a style='cursor:hand;color:blue;' onClick="TPI_openwindow('http://epub.cnki.net/grid2008/knowledgenet.aspx?sdb=CJFD&sfield=%e8%8b%b1%e6%96%87%e4%bd%9c%e8%80%85&skey=Guangzhou', 'knet','status=yes,scrollbars=yes,width=375,height=250')">Guangzhou 510260</a>;<a style='cursor:hand;color:blue;' onClick="TPI_openwindow('http://epub.cnki.net/grid2008/knowledgenet.aspx?sdb=CJFD&sfield=%e8%8b%b1%e6%96%87%e4%bd%9c%e8%80%85&skey=China', 'knet','status=yes,scrollbars=yes,width=375,height=250')">China</a></td></tr><tr><td> </td><td>　<abstract>jective To learn the reason and associated factors of medicinal hematuria in children Methods The clinical data of 32 children with medicinal hematuria were analysed retrospectively. Results The heat-expelling and pain-relieving drugs were major causes that induced children medicinal hematuria(46.9%). Cephalosporins were the secondary(21. 9%). Aminoglucosides antibiotics were the third (15.6%). In addition, 3 of whom are induced hematuria by sulfonamides, norfloxacin, the Chinese medicine of Kang-bing-du Chong-ji, respectively. Some of medicinal hematuria occurrences were associated with the drug doses, but Some of medicinal hematuria have nothing to do with the doses. 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